Reactome | AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

Stable Identifier

R-HSA-8848582

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester

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AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of HXOL (hexadecanol) and PALM-CoA (palmitoyl-CoA) to form the wax monoester palmityl palmitate. The enzyme also acts efficiently on other long-chain fatty alcohols and fatty acyl CoAs. It is abundant in skin and is thought to play a central role in the synthesis of wax molecules that protect the skin from drying (Cheng & Russell 2004; Turkish et al. 2005; Yen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15220349	Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family Cheng, JB, Russell, DW	J. Biol. Chem.	2004
16106050	A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters Yen, CL, Brown, CH, Monetti, M, Farese, RV	J. Lipid Res.	2005
15671038	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, AR, Henneberry, AL, Cromley, D, Padamsee, M, Oelkers, P, Bazzi, H, Christiano, AM, Billheimer, JT, Sturley, SL	J. Biol. Chem.	2005