Reactome | CAPN2 [cytosol]

CAPN2 [cytosol]

Stable Identifier

R-HSA-8848630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calpain-2 catalytic subunit ecNumber3.4.22.53/ecNumber, CAN2_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        Calpain activation (Homo sapiens)
        
        Calpain1,Calpain2 [cytosol] (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17655 CAPN2

Gene Names

CAPN2, CANPL2

Chain

initiator methionine:, propeptide:2-19, chain:20-700

Reference Genes

BioGPS Gene:824 CAPN2

COSMIC (genes):CAPN2 CAPN2

CTD Gene:824 CAPN2

dbSNP Gene:824 CAPN2

ENSEMBL:ENSG00000162909 CAPN2

ENSEMBL_homo_sapiens_GENE:ENSG00000162909.18 CAPN2

HGNC:1479 CAPN2

KEGG Gene (Homo sapiens):824 CAPN2

Monarch:824 CAPN2

NCBI Gene:824 CAPN2

OMIM:114230 CAPN2

UCSC:P17655 CAPN2

Reference Transcript

Other Identifiers

11718977_a_at

11718978_x_at

11741128_a_at

11741129_s_at

11750167_a_at

16677863

208683_PM_at

208683_at

2382116

2382119

2382120

2382121

2382124

2382146

2382147

2382152

2382153

2382155

2382156

2382157

2382160

2382161

2382166

2382167

2382171

2382172

2382176

2382177

2382181

2382182

2382184

2382185

2382192

2382193

2382194

2382195

2382196

37001_at

7909967

824

A_23_P23924

GE57878

GO:0000785

GO:0001666

GO:0001824

GO:0003824

GO:0004198

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005694

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006508

GO:0006629

GO:0007010

GO:0007520

GO:0007565

GO:0008092

GO:0008233

GO:0008234

GO:0009612

GO:0009897

GO:0010666

GO:0012501

GO:0016020

GO:0016540

GO:0016787

GO:0019899

GO:0022414

GO:0030154

GO:0030163

GO:0030425

GO:0030864

GO:0031143

GO:0032675

GO:0035458

GO:0042542

GO:0042995

GO:0043025

GO:0043226

GO:0044877

GO:0045121

GO:0046872

GO:0048266

GO:0048856

GO:0051493

GO:0051603

GO:0051604

GO:0070062

GO:0071222

GO:0071230

GO:0097038

GO:0110158

GO:0140096

GO:1901741

GO:2001247

HMNXSV003006913

ILMN_1716057

M23254_at

PH_hs_0016936

TC01001838.hg

g511636_3p_at

Participates

as a member of

CAPN [cytosol] (Homo sapiens)

as a component of

Calpain2 [cytosol] (Homo sapiens)

Other forms of this molecule

CAPN2 [plasma membrane]

Inferred To

CAPN2 [cytosol] (Bos taurus)

CAPN2 [cytosol] (Canis familiaris)

CAPN2 [cytosol] (Mus musculus)

CAPN2 [cytosol] (Rattus norvegicus)

CAPN2 [cytosol] (Sus scrofa)

zgc:113590 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001739.2, NP_001139540.1

Guide to Pharmacology - Targets

2337

OpenTargets

ENSG00000162909

ZINC - Substances

CAN2_HUMAN

ZINC target

P17655

PRO

P17655

PDB

1KFX, 2NQA, 1KFU

GeneCards

P17655

HPA

ENSG00000162909-CAPN2

Ensembl

ENSG00000162909, ENST00000433674, ENSP00000413158, ENSP00000295006, ENST00000295006

Pharos - Targets

P17655

ZINC - Predictions - Purchasable

CAN2_HUMAN

HMDB Protein

HMDBP07545

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	17
UniProt:P20810 CAST	1	CAST [cytosol] (R-HSA-8848644)	0.589	2
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3