PTK6 phosphorylates ARAP1

Stable Identifier
R-HSA-8848873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTK6 phosphorylates ARAP1
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ARAP1 is implicated in the endocytosis of EGFR, as the complex formation betwen ARAP1 and CIN85 inhibits CBL-mediated targeting of EGFR to the early endosome/lysosome pathway (Yoon et al. 2011). PTK6 phosphorylates ARAP1 on tyrosine residue Y231, resulting in the inhibition of EGFR endocytosis and, hence, prolonged EGFR signaling (Kang et al. 2010).
Literature References
PubMed ID Title Journal Year
20554524 PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1

Randazzo, PA, Lee, ES, Lee, ST, Yoon, HY, Kang, SA

J. Biol. Chem. 2010
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Output
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Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:ARAP1 [cytosol]

Physical Entity
p-Y342-PTK6:ARAP1 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates ARAP1 (Bos taurus)
PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)
PTK6 phosphorylates ARAP1 (Mus musculus)
PTK6 phosphorylates ARAP1 (Rattus norvegicus)
PTK6 phosphorylates ARAP1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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