Reactome | LGALS3BP [platelet dense granule lumen]

LGALS3BP [platelet dense granule lumen]

Stable Identifier

R-HSA-8848916

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet dense granule lumen

Synonyms

Galectin-3-binding protein, LG3BP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08380 LGALS3BP

Gene Names

LGALS3BP, M2BP

Chain

signal peptide:1-18, chain:19-585

Reference Genes

BioGPS Gene:3959 LGALS3BP

COSMIC (genes):LGALS3BP LGALS3BP

CTD Gene:3959 LGALS3BP

dbSNP Gene:3959 LGALS3BP

ENSEMBL:ENSG00000108679 LGALS3BP

ENSEMBL_homo_sapiens_GENE:ENSG00000108679.13 LGALS3BP

HGNC:6564 LGALS3BP

KEGG Gene (Homo sapiens):3959 LGALS3BP

Monarch:3959 LGALS3BP

NCBI Gene:3959 LGALS3BP

OMIM:600626 LGALS3BP

UCSC:Q08380 LGALS3BP

Reference Transcript

RefSeq:NM_005567.3 LGALS3BP

Other Identifiers

11715370_s_at

16849576

200923_PM_at

200923_at

3772749

3772750

3772751

3772752

3772753

3772754

3772756

3772757

3772760

3772762

3772763

3772768

3772772

37754_at

3959

8018975

A_23_P15357

GE57621

GO:0005044

GO:0005515

GO:0005576

GO:0005615

GO:0006897

GO:0006968

GO:0007155

GO:0007165

GO:0016020

GO:0016192

GO:0023052

GO:0030312

GO:0031012

GO:0031089

GO:0031410

GO:0038024

GO:0043226

GO:0062023

GO:0070062

GO:0072562

HMNXSV003021308

ILMN_1659688

L13210_at

PH_hs_0004589

TC17001924.hg

g6006016_3p_at

Participates

as a member of

Platelet dense granule content [platelet dense granule lumen] (Homo sapiens)

Other forms of this molecule

LGALS3BP [extracellular region]

Inferred To

triA [platelet dense granule lumen] (Dictyostelium discoideum)

Homologues of LGALS3BP [platelet dense granule lumen] (Dictyostelium discoideum)

Tango10 [platelet dense granule lumen] (Drosophila melanogaster)

LGALS3BP [platelet dense granule lumen] (Bos taurus)

LGALS3BP [platelet dense granule lumen] (Dictyostelium discoideum)

LGALS3BP [platelet dense granule lumen] (Sus scrofa)

CANT1 [platelet dense granule lumen] (Canis familiaris)

lgals3bpa [platelet dense granule lumen] (Danio rerio)

Lgals3bp [platelet dense granule lumen] (Mus musculus)

Lgals3bp [platelet dense granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_005558.1

OpenTargets

ENSG00000108679

GeneCards

Q08380

HPA

ENSG00000108679-LGALS3BP

Ensembl

ENSG00000108679, ENST00000262776, ENSP00000262776

PRO

Q08380

Pharos - Targets

Q08380

PDB

1BY2, 6GFB

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96RR1 TWNK	1	TWNK [mitochondrial matrix] (R-HSA-1592222)	0.589	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.577	18
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2
UniProt:Q2M1P5 KIF7	1	KIF7 [ciliary tip] (R-HSA-5610395)	0.527	2
UniProt:Q9BYK8 HELZ2	1	HELZ2 [nucleoplasm] (R-HSA-442499)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.499	2
UniProt:Q9BZR8 BCL2L14	1	BCL2L14 [cytosol] (R-HSA-6791317)	0.499	2

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