Reactome | PTK6 phosphorylates KHDRBS1

PTK6 phosphorylates KHDRBS1

Stable Identifier

R-HSA-8848975

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y435, Y440 and Y443, located within the nuclear localization signal (NLS) of KHDRBS1 (Lukong et al. 2005). PTK6-mediated phosphorylation inhibits the interaction of KHDRBS1 with RNA (Derry et al. 2000, Coyle et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10913193	Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability Derry, JJ, Richard, S, Valderrama Carvajal, H, Ye, X, Vasioukhin, V, Cochrane, AW, Chen, T, Tyner, AL	Mol. Cell. Biol.	2000
16179349	Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression Lukong, KE, Larocque, D, Tyner, AL, Richard, S	J. Biol. Chem.	2005
12482964	Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK Coyle, JH, Guzik, BW, Bor, YC, Jin, L, Eisner-Smerage, L, Taylor, SJ, Rekosh, D, Hammarskjold, ML	Mol. Cell. Biol.	2003