PTK6 phosphorylates KHDRBS1

Stable Identifier
Reaction [transition]
Homo sapiens
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PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y435, Y440 and Y443, located within the nuclear localization signal (NLS) of KHDRBS1 (Lukong et al. 2005). PTK6-mediated phosphorylation inhibits the interaction of KHDRBS1 with RNA (Derry et al. 2000, Coyle et al. 2003).

Literature References
PubMed ID Title Journal Year
16179349 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression

Lukong, KE, Larocque, D, Tyner, AL, Richard, S

J. Biol. Chem. 2005
10913193 Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Derry, JJ, Richard, S, Valderrama Carvajal, H, Ye, X, Vasioukhin, V, Cochrane, AW, Chen, T, Tyner, AL

Mol. Cell. Biol. 2000
12482964 Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK

Coyle, JH, Guzik, BW, Bor, YC, Jin, L, Eisner-Smerage, L, Taylor, SJ, Rekosh, D, Hammarskjold, ML

Mol. Cell. Biol. 2003
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:KHDRBS1 [nucleoplasm]

Orthologous Events
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