PTK6 phosphorylates ARHGAP35

Stable Identifier
R-HSA-8849068
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTK6 phosphorylates ARHGAP35
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Activated PTK6 (BRK) phosphorylates ARHGAP35, a Rho GTPase activating protein, on tyrosine residue Y1105 (Shen et al. 2005).
Literature References
PubMed ID Title Journal Year
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Kuo, ML, Li, FY, Settleman, J, Shen, CH, Chen, HY, Chang, CC, Chen, RH, Lin, MS

Cancer Res. 2008
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of p-Y342-PTK6:ARHGAP35 [cytosol]

Physical Entity
p-Y342-PTK6:ARHGAP35 [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK6 phosphorylates ARHGAP35 (Bos taurus)
PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)
PTK6 phosphorylates ARHGAP35 (Danio rerio)
PTK6 phosphorylates ARHGAP35 (Mus musculus)
PTK6 phosphorylates ARHGAP35 (Rattus norvegicus)
PTK6 phosphorylates ARHGAP35 (Sus scrofa)
PTK6 phosphorylates ARHGAP35 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-11)
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