ARHGAP35 binds RASA1

Stable Identifier
R-HSA-8849094
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ARHGAP35 binds RASA1
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PTK6 (BRK) mediated phosphorylation of ARHGAP35 (p190 Rho GAP) promotes binding of ARHGAP35 to RASA1 (p120 RAS GAP). Binding to ARHGAP35 inhibits RASA1-mediated stimulation of RAS GTPase activity, resulting in prolonged RAS signaling (Shen et al. 2008).
Literature References
PubMed ID Title Journal Year
18829532 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

Kuo, ML, Li, FY, Settleman, J, Shen, CH, Chen, HY, Chang, CC, Chen, RH, Lin, MS

Cancer Res. 2008
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Orthologous Events
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ARHGAP35 binds RASA1 (Drosophila melanogaster)
ARHGAP35 binds RASA1 (Gallus gallus)
ARHGAP35 binds RASA1 (Mus musculus)
ARHGAP35 binds RASA1 (Rattus norvegicus)
ARHGAP35 binds RASA1 (Sus scrofa)
ARHGAP35 binds RASA1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-05)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2015-12-12)
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