Reactome | THOC5 [nucleoplasm]

THOC5 [nucleoplasm]

Stable Identifier

R-HSA-8849111

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

THO complex subunit 5 homolog, THOC5_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        THO complex [nucleoplasm] (Homo sapiens)
        
        THOC5 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        THO complex [nucleoplasm] (Homo sapiens)
        
        THOC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13769 THOC5

Gene Names

THOC5, C22orf19, KIAA0983

Chain

initiator methionine:1, chain:2-683

Reference Genes

BioGPS Gene:8563 THOC5

COSMIC (genes):THOC5 THOC5

CTD Gene:8563 THOC5

dbSNP Gene:8563 THOC5

ENSEMBL:ENSG00000100296 THOC5

ENSEMBL:ENSG00000100296.14 THOC5

HGNC:19074 THOC5

KEGG Gene (Homo sapiens):8563 THOC5

Monarch:8563 THOC5

NCBI Gene:8563 THOC5

OMIM:612733 THOC5

UCSC:Q13769 THOC5

Reference Transcript

Other Identifiers

11735792_a_at

16933630

209418_PM_s_at

209418_s_at

209419_3p_at

209419_PM_at

209419_at

3956858

3956859

3956860

3956861

3956862

3956863

3956865

3956866

3956867

3956868

3956869

3956870

3956872

3956873

3956874

3956878

3956880

3956883

3956884

3956887

3956888

3956889

3956890

3956891

3956892

3956895

3956896

3956897

3956898

40383_at

69047_at

8075239

8563

A_23_P109470

A_24_P228700

GE62024

GO:0000346

GO:0000347

GO:0000445

GO:0000781

GO:0002376

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006397

GO:0006406

GO:0006913

GO:0008380

GO:0016071

GO:0023052

GO:0030154

GO:0030224

GO:0032786

GO:0043226

GO:0046784

GO:0048856

GO:0051028

GO:0060215

GO:2000002

HMNXSV003014990

HMNXSV003052644

ILMN_1667883

ILMN_2393169

L18972_at

PH_hs_0035454

TC22001487.hg

g13177658_3p_a_at

g4589609_3p_at

g4589609_3p_x_at

Participates

as a component of

THO complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

THOC5 [cytosol]

p-Y-THOC5 [cytosol]

Inferred To

thoc-5 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of THOC5 [nucleoplasm] (Schizosaccharomyces pombe)

thoc5 [nucleoplasm] (Danio rerio)

thoc5 [nucleoplasm] (Drosophila melanogaster)

thoc5 [nucleoplasm] (Xenopus tropicalis)

THOC5 [nucleoplasm] (Bos taurus)

THOC5 [nucleoplasm] (Canis familiaris)

THOC5 [nucleoplasm] (Gallus gallus)

THOC5 [nucleoplasm] (Sus scrofa)

Thoc5 [nucleoplasm] (Mus musculus)

Thoc5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001002878.1, NP_001002877.1, NP_001002879.1, NP_003669.4

OpenTargets

ENSG00000100296

GeneCards

Q13769

HPA

ENSG00000100296-THOC5

Ensembl

ENST00000490103, ENSG00000100296, ENSP00000420306, ENSP00000380969, ENST00000397873, ENSP00000380970, ENST00000397871, ENST00000397872, ENSP00000380971

PRO

Q13769

Pharos - Targets

Q13769

PDB

7APK

HMDB Protein

HMDBP14137

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.888	10
UniProt:Q6I9Y2 THOC7	1	THOC7 [nucleoplasm] (R-HSA-8849145)	0.649	9
UniProt:Q8NI27 THOC2	1	THOC2 [nucleoplasm] (R-HSA-8849134)	0.643	4
UniProt:Q53F19 NCBP3			0.643	7
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.623	5
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.593	4
UniProt:Q96J01 THOC3	1	THOC3 [nucleoplasm] (R-HSA-8849121)	0.527	2
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.462	4