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THOC3 [nucleoplasm]
Stable Identifier
R-HSA-8849121
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
THO complex subunit 3, THOC3_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96J01 THOC3
Gene Names
THOC3
Chain
initiator methionine:, chain:2-351
Reference Genes
BioGPS Gene:84321 THOC3
COSMIC (genes):THOC3 THOC3
CTD Gene:84321 THOC3
dbSNP Gene:84321 THOC3
ENSEMBL:ENSG00000051596 THOC3
ENSEMBL_homo_sapiens_GENE:ENSG00000051596.10 THOC3
HGNC:19072 THOC3
KEGG Gene (Homo sapiens):84321 THOC3
Monarch:84321 THOC3
NCBI Gene:84321 THOC3
OMIM:606929 THOC3
UCSC:Q96J01 THOC3
Reference Transcript
RefSeq:NM_032361.3 THOC3
Other Identifiers
11756139_s_at
11760126_at
224623_PM_at
224623_at
2843418
2843419
2843420
2843422
2843424
2843425
2843426
2843428
2843429
2843430
2843431
2843432
2843433
2843434
2843435
2843436
2888115
2888116
2888117
2888118
2888119
2888120
2888121
2888122
2888123
2888124
2888128
2888130
2888131
2888132
2888133
2888134
57089_at
8110408
8115886
84321
A_33_P3336642
GE56994
GO:0000346
GO:0000445
GO:0000781
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006397
GO:0006406
GO:0006913
GO:0008380
GO:0016071
GO:0016607
GO:0043226
GO:0051028
HMNXSV003032962
HMNXSV003056578
Hs.19574.0.S1_3p_at
ILMN_1688903
ILMN_1691949
ILMN_1813246
ILMN_2415926
PH_hs_0027092
PH_hs_0037305
TC05001024.hg
TC05002766.hg
Participates
as a component of
THO complex [nucleoplasm] (Homo sapiens)
Inferred To
AAC3 [nucleoplasm]
(Dictyostelium discoideum)
Thoc3 [nucleoplasm]
(Mus musculus)
THOC3 [nucleoplasm]
(Bos taurus)
THOC3 [nucleoplasm]
(Canis familiaris)
THOC3 [nucleoplasm]
(Gallus gallus)
THOC3 [nucleoplasm]
(Rattus norvegicus)
THOC3 [nucleoplasm]
(Sus scrofa)
thoc3 [nucleoplasm]
(Danio rerio)
tex [nucleoplasm]
(Drosophila melanogaster)
thoc-3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_115737.1
OpenTargets
ENSG00000051596
HPA
ENSG00000051596-THOC3
GeneCards
Q96J01
Ensembl
ENST00000265097
,
ENST00000513482
,
ENSP00000265097
,
ENSP00000422243
,
ENSG00000051596
PRO
Q96J01
Pharos - Targets
Q96J01
PDB
7APK
,
7ZNL
,
7ZNK
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13769 THOC5
3
THOC5 [nucleoplasm]
(R-HSA-8849111)
THOC5 [cytosol]
(R-HSA-9682751)
p-Y-THOC5 [cytosol]
(R-HSA-9682738)
0.643
4
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
3
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