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THOC1 [nucleoplasm]
Stable Identifier
R-HSA-8849130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
THO complex subunit 1, THOC1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96FV9 THOC1
Gene Names
THOC1, HPR1
Chain
chain:1-657
Reference Genes
BioGPS Gene:9984 THOC1
COSMIC (genes):THOC1 THOC1
CTD Gene:9984 THOC1
dbSNP Gene:9984 THOC1
ENSEMBL:ENSG00000079134 THOC1
HGNC:19070 THOC1
KEGG:hsa:9984 THOC1
Monarch:9984 THOC1
NCBI Gene:9984 THOC1
OMIM:606930 THOC1
UCSC:Q96FV9 THOC1
Reference Transcript
RefSeq:NM_005131.2 THOC1
Other Identifiers
11719136_at
11719137_a_at
16853377
204064_PM_at
204064_at
3795683
3795684
3795685
3795686
3795687
3795688
3795689
3795690
3795691
3795692
3795693
3795694
3795695
3795696
3795697
3795698
3795699
3795700
3795701
3795710
3795711
3795712
3795713
3795714
3795715
3795716
3795717
3795718
3795719
3795720
3795721
3795723
3795724
3795725
3795726
3795728
3795729
3795730
40242_at
8021924
9984
A_23_P78372
GE57740
GO:0000346
GO:0000347
GO:0000445
GO:0000781
GO:0003677
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006397
GO:0006406
GO:0006913
GO:0006915
GO:0007165
GO:0008380
GO:0012501
GO:0016071
GO:0016363
GO:0016607
GO:0043226
GO:0051028
HMNXSV003042681
ILMN_1802157
L36529_at
PH_hs_0000205
TC18000272.hg
g4826881_3p_at
Participates
as a component of
THO complex [nucleoplasm] (Homo sapiens)
Inferred To
THOC1 [nucleoplasm]
(Bos taurus)
THOC1 [nucleoplasm]
(Canis familiaris)
THOC1 [nucleoplasm]
(Gallus gallus)
THOC1 [nucleoplasm]
(Sus scrofa)
thoc1 [nucleoplasm]
(Danio rerio)
thoc1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of THOC1 [nucleoplasm]
(Rattus norvegicus)
Hpr1 [nucleoplasm]
(Drosophila melanogaster)
thoc-1 [nucleoplasm]
(Caenorhabditis elegans)
Thoc1 [nucleoplasm]
(Mus musculus)
Cross References
RefSeq
NP_005122.2
ENSEMBL
ENST00000261600
,
ENSP00000261600
OpenTargets
ENSG00000079134
HPA
ENSG00000079134-THOC1
PRO
Q96FV9
Pharos - Targets
Q96FV9
GlyGen
Q96FV9
PDB
7ZNL
,
7ZNK
,
1WXP
,
7APK
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13769 THOC5
3
THOC5 [nucleoplasm]
(R-HSA-8849111)
THOC5 [cytosol]
(R-HSA-9682751)
p-Y-THOC5 [cytosol]
(R-HSA-9682738)
0.919
12
UniProt:Q13838 DDX39B
2
DDX39B [nucleoplasm]
(R-HSA-8849139)
DDX39B [cytosol]
(R-HSA-9715154)
0.788
5
UniProt:Q86V81 ALYREF
2
ALYREF [cytosol]
(R-HSA-158482)
ALYREF [nucleoplasm]
(R-HSA-156649)
0.749
7
UniProt:P82979 SARNP
1
SARNP [nucleoplasm]
(R-HSA-8849146)
0.643
3
UniProt:O75478 TADA2A
1
TADA2A [nucleoplasm]
(R-HSA-3662284)
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.556
3
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.462
4
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