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THOC6 [nucleoplasm]
Stable Identifier
R-HSA-8849144
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
THO complex subunit 6 homolog, THOC6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
THO complex [nucleoplasm] (Homo sapiens)
THOC6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86W42 THOC6
Gene Names
THOC6, WDR58, PSEC0006
Chain
chain:1-341
Reference Genes
BioGPS Gene:79228 THOC6
COSMIC (genes):THOC6 THOC6
CTD Gene:79228 THOC6
dbSNP Gene:79228 THOC6
ENSEMBL:ENSG00000131652 THOC6
ENSEMBL_homo_sapiens_GENE:ENSG00000131652.14 THOC6
HGNC:28369 THOC6
KEGG Gene (Homo sapiens):79228 THOC6
Monarch:79228 THOC6
NCBI Gene:79228 THOC6
OMIM:615403 THOC6
UCSC:Q86W42 THOC6
Reference Transcript
RefSeq:NM_024339.4 THOC6
RefSeq:NM_001142350.2 THOC6
RefSeq:NM_001347704.1 THOC6
RefSeq:NM_001347703.1 THOC6
Other Identifiers
11728714_a_at
16815316
218848_PM_at
218848_at
3645566
3645567
3645568
3645569
3645570
3645571
3645573
3645574
3645576
3645578
3645579
3645580
3645581
3645582
3645583
3645584
3645585
3645586
3645587
43091_at
79228
7992795
GO:0000346
GO:0000347
GO:0000445
GO:0000781
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006397
GO:0006406
GO:0006913
GO:0006915
GO:0007417
GO:0008380
GO:0012501
GO:0016071
GO:0016604
GO:0016607
GO:0043226
GO:0048856
GO:0051028
HMNXSV003015475
ILMN_1679880
PH_hs_0035928
TC16000096.hg
g13236588_3p_at
Participates
as a component of
THO complex [nucleoplasm] (Homo sapiens)
Inferred To
THOC6 [nucleoplasm]
(Bos taurus)
THOC6 [nucleoplasm]
(Canis familiaris)
THOC6 [nucleoplasm]
(Sus scrofa)
thoc6 [nucleoplasm]
(Danio rerio)
thoc6 [nucleoplasm]
(Dictyostelium discoideum)
thoc6 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of THOC6 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of THOC6 [nucleoplasm]
(Gallus gallus)
Thoc6 [nucleoplasm]
(Mus musculus)
Thoc6 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_001135822.1
,
NP_077315.2
,
NP_001334632.1
,
NP_001334633.1
OpenTargets
ENSG00000131652
GeneCards
Q86W42
HPA
ENSG00000131652-THOC6
Ensembl
ENST00000575576
,
ENSP00000460015
,
ENSP00000326531
,
ENSP00000458295
,
ENST00000253952
,
ENST00000574549
,
ENSP00000253952
,
ENST00000326266
,
ENSG00000131652
PRO
Q86W42
Pharos - Targets
Q86W42
Orphanet
22371
PDB
7APK
,
7ZNL
,
7ZNK
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