Reactome | THOC7 [nucleoplasm]

THOC7 [nucleoplasm]

Stable Identifier

R-HSA-8849145

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

THO complex subunit 7 homolog, THOC7_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        THO complex [nucleoplasm] (Homo sapiens)
        
        THOC7 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        THO complex [nucleoplasm] (Homo sapiens)
        
        THOC7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6I9Y2 THOC7

Gene Names

THOC7, NIF3L1BP1

Chain

initiator methionine:, chain:2-204

Reference Genes

BioGPS Gene:80145 THOC7

COSMIC (genes):THOC7 THOC7

CTD Gene:80145 THOC7

dbSNP Gene:80145 THOC7

ENSEMBL:ENSG00000163634 THOC7

ENSEMBL_homo_sapiens_GENE:ENSG00000163634.12 THOC7

HGNC:29874 THOC7

KEGG Gene (Homo sapiens):80145 THOC7

Monarch:80145 THOC7

NCBI Gene:80145 THOC7

OMIM:611965 THOC7

UCSC:Q6I9Y2 THOC7

Reference Transcript

Other Identifiers

11719380_a_at

16955754

218334_PM_at

218334_at

2679797

2679798

2679799

2679800

2679802

2679804

2679805

2679806

2679807

49289_s_at

80145

8088526

A_32_P136402

GE83074

GO:0000346

GO:0000347

GO:0000445

GO:0000781

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006397

GO:0006406

GO:0006913

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0051028

HMNXSV003034848

PH_hs_0014941

TC03001521.hg

g13376622_3p_at

Participates

as a component of

THO complex [nucleoplasm] (Homo sapiens)

Inferred To

THOC7 [nucleoplasm] (Bos taurus)

THOC7 [nucleoplasm] (Canis familiaris)

THOC7 [nucleoplasm] (Gallus gallus)

THOC7 [nucleoplasm] (Sus scrofa)

thoc7 [nucleoplasm] (Danio rerio)

thoc7 [nucleoplasm] (Dictyostelium discoideum)

thoc7 [nucleoplasm] (Drosophila melanogaster)

Thoc7 [nucleoplasm] (Mus musculus)

Thoc7 [nucleoplasm] (Rattus norvegicus)

thoc-7 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001272333.1, NP_079351.2

OpenTargets

ENSG00000163634

GeneCards

Q6I9Y2

HPA

ENSG00000163634-THOC7

Ensembl

ENSG00000163634, ENSP00000295899, ENST00000295899

PRO

Q6I9Y2

Pharos - Targets

Q6I9Y2

PDB

7ZNL, 7ZNK, 7APK

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.649	9
UniProt:Q13838 DDX39B	2	DDX39B [cytosol] (R-HSA-9715154) DDX39B [nucleoplasm] (R-HSA-8849139)	0.643	3
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	2