Reactome | CHTOP [nucleoplasm]

CHTOP [nucleoplasm]

Stable Identifier

R-HSA-8849147

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromatin target of PRMT1 protein, CHTOP_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3Y2 CHTOP

Gene Names

CHTOP, C1orf77, FOP, HT031, PP7704

Chain

initiator methionine:1, chain:2-248

Reference Genes

BioGPS Gene:26097 CHTOP

COSMIC (genes):CHTOP CHTOP

CTD Gene:26097 CHTOP

dbSNP Gene:26097 CHTOP

ENSEMBL:ENSG00000160679 CHTOP

HGNC:24511 CHTOP

KEGG:hsa:26097 CHTOP

Monarch:26097 CHTOP

NCBI Gene:26097 CHTOP

OMIM:614206 CHTOP

UCSC:Q9Y3Y2 CHTOP

Reference Transcript

Participates

as an input of

TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)

as a component of

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Inferred To

C1orf77 [nucleoplasm] (Sus scrofa)

Chtop [nucleoplasm] (Mus musculus)

Chtop [nucleoplasm] (Rattus norvegicus)

CHTOP [nucleoplasm] (Canis familiaris)

CHTOP [nucleoplasm] (Gallus gallus)

Ghost homologue of CHTOP [nucleoplasm] (Bos taurus)

Ghost homologue of CHTOP [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CHTOP [nucleoplasm] (Danio rerio)

Ghost homologue of CHTOP [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_056422.2, NP_001193541.1, NP_001304006.1, NP_001231593.1

OpenTargets

ENSG00000160679

ENSEMBL

ENSP00000357683, ENSP00000385228, ENST00000403433, ENST00000368690, ENSP00000357679, ENST00000368694, ENSG00000160679

HPA

ENSG00000160679-CHTOP

GeneCards

CHTOP

PRO

Q9Y3Y2

Pharos - Targets

Q9Y3Y2

GlyGen

Q9Y3Y2

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13838 DDX39B	2	DDX39B [nucleoplasm] (R-HSA-8849139) DDX39B [cytosol] (R-HSA-9715154)	0.873	9
UniProt:P84090 ERH			0.854	8
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.691	7
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.677	9
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.669	6
UniProt:Q53F19 NCBP3			0.669	5
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.662	6
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.653	9
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.59	2
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.564	2
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.564	2
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.564	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.564	3
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.564	2
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.564	2
UniProt:Q8NI27 THOC2	1	THOC2 [nucleoplasm] (R-HSA-8849134)	0.564	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.556	3
UniProt:Q14739 LBR	4	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) LBR [endosome membrane] (R-HSA-9715094)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	6
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.527	3
UniProt:Q9UPE1 SRPK3			0.527	2
UniProt:Q9ULV3 CIZ1			0.527	3
UniProt:Q9NR22 ANM8			0.527	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	2
UniProt:Q9UKK6 NXT1	2	NXT1 [cytosol] (R-HSA-8849122) NXT1 [nucleoplasm] (R-HSA-8849151)	0.499	4

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