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CHTOP [nucleoplasm]
Stable Identifier
R-HSA-8849147
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromatin target of PRMT1 protein, CHTOP_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Homo sapiens)
NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Homo sapiens)
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
CHTOP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3Y2 CHTOP
Gene Names
CHTOP, C1orf77, FOP, HT031, PP7704
Chain
initiator methionine:, chain:2-248
Reference Genes
COSMIC (genes):CHTOP CHTOP
dbSNP Gene:26097 CHTOP
ENSEMBL:ENSG00000160679 CHTOP
Participates
as an input of
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
as a component of
TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
TREX (minus DDX39B) [nucleoplasm] (Homo sapiens)
as an output of
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
Inferred To
Chtop [nucleoplasm]
(Mus musculus)
Chtop [nucleoplasm]
(Rattus norvegicus)
CHTOP [nucleoplasm]
(Canis familiaris)
CHTOP [nucleoplasm]
(Sus scrofa)
Ghost homologue of CHTOP [nucleoplasm]
(Bos taurus)
Ghost homologue of CHTOP [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of CHTOP [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CHTOP [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of CHTOP [nucleoplasm]
(Gallus gallus)
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13838 DDX39B
2
DDX39B [nucleoplasm]
(R-HSA-8849139)
DDX39B [cytosol]
(R-HSA-9715154)
0.831
8
UniProt:P84090 ERH
0.75
6
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.653
9
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.59
2
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.564
5
UniProt:Q86V81 ALYREF
2
ALYREF [cytosol]
(R-HSA-158482)
ALYREF [nucleoplasm]
(R-HSA-156649)
0.558
8
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.556
3
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.556
3
UniProt:Q9UPE1 SRPK3
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
6
UniProt:Q53F19 NCBP3
0.527
4
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.527
2
UniProt:Q9UKK6 NXT1
2
NXT1 [cytosol]
(R-HSA-8849122)
NXT1 [nucleoplasm]
(R-HSA-8849151)
0.499
4
UniProt:Q13769 THOC5
3
THOC5 [nucleoplasm]
(R-HSA-8849111)
THOC5 [cytosol]
(R-HSA-9682751)
p-Y-THOC5 [cytosol]
(R-HSA-9682738)
0.462
4
UniProt:Q96FV9 THOC1
1
THOC1 [nucleoplasm]
(R-HSA-8849130)
0.462
4
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