Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CASC3 [nucleoplasm]
Stable Identifier
R-HSA-8849148
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein CASC3, CASC3_HUMAN, MLN51
Locations in the PathwayBrowser for interactor UniProt:Q9BRP8 PYM1
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
CASC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15234 CASC3
Gene Names
CASC3, MLN51
Chain
chain:1-703
Reference Genes
BioGPS Gene:22794 CASC3
COSMIC (genes):CASC3 CASC3
CTD Gene:22794 CASC3
dbSNP Gene:22794 CASC3
ENSEMBL:ENSG00000108349 CASC3
ENSEMBL_homo_sapiens_GENE:ENSG00000108349.17 CASC3
HGNC:17040 CASC3
KEGG Gene (Homo sapiens):22794 CASC3
Monarch:22794 CASC3
NCBI Gene:22794 CASC3
OMIM:606504 CASC3
UCSC:O15234 CASC3
Reference Transcript
RefSeq:XM_005257163.1 CASC3
RefSeq:NM_007359.4 CASC3
Other Identifiers
11715736_s_at
11715737_at
11752377_a_at
16833996
207842_PM_s_at
207842_s_at
22794
3720784
3720785
3720786
3720788
3720789
3720796
3720797
3720798
3720799
3720800
3720801
3720802
3720804
3720805
3720807
3720809
3720810
3720812
3720813
38437_at
8007028
A_23_P374284
A_23_P374288
A_24_P125353
GE60060
GO:0000184
GO:0000398
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005681
GO:0005737
GO:0005829
GO:0006397
GO:0006406
GO:0006417
GO:0006913
GO:0008298
GO:0008380
GO:0010494
GO:0016071
GO:0016607
GO:0019899
GO:0030425
GO:0031625
GO:0031965
GO:0035145
GO:0036464
GO:0042802
GO:0042995
GO:0043226
GO:0048471
GO:0051028
GO:0071006
GO:1990904
GO:2000622
HMNXSV003008421
ILMN_1665004
PH_hs_0004765
TC17000490.hg
X80199_at
g6678887_3p_a_at
Participates
as an input of
Formation of the Spliceosomal B* complex (Homo sapiens)
as a component of
Core EJC [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CASC3 [cytosol]
Inferred To
CASC3 [nucleoplasm]
(Bos taurus)
CASC3 [nucleoplasm]
(Canis familiaris)
CASC3 [nucleoplasm]
(Gallus gallus)
CASC3 [nucleoplasm]
(Sus scrofa)
casc3 [nucleoplasm]
(Danio rerio)
casc3 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of CASC3 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CASC3 [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of CASC3 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of CASC3 [nucleoplasm]
(Schizosaccharomyces pombe)
Casc3 [nucleoplasm]
(Mus musculus)
Casc3 [nucleoplasm]
(Rattus norvegicus)
casc-3 [nucleoplasm]
(Caenorhabditis elegans)
btz [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_031385.2
,
XP_005257220.1
OpenTargets
ENSG00000108349
GeneCards
O15234
HPA
ENSG00000108349-CASC3
Ensembl
ENSG00000108349
,
ENST00000264645
,
ENSP00000264645
PRO
O15234
Pharos - Targets
O15234
PDB
2HYI
,
2XB2
,
3EX7
,
7W5B
,
2J0S
,
6ICZ
,
7W5A
,
7W59
,
2J0U
,
2J0Q
,
5YZG
,
5XJC
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.98
37
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.966
27
UniProt:Q9Y5S9-1 RBM8A
0.863
12
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.857
6
UniProt:Q9BZI7-2 UPF3B
0.79
10
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.766
6
UniProt:Q9HAU5 UPF2
1
UPF2 [cytosol]
(R-HSA-927799)
0.704
7
UniProt:Q9BZI7 UPF3B
2
UPF3B [nucleoplasm]
(R-HSA-156776)
UPF3B [cytosol]
(R-HSA-159258)
0.643
3
UniProt:Q9BRP8 PYM1
0.621
4
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
5
UniProt:Q8IYD1 GSPT2
1
GSPT2 [cytosol]
(R-HSA-143379)
0.527
3
UniProt:Q8N6W0 CELF5
0.527
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.527
2
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text