Reactome | EIF4A3 [nucleoplasm]

EIF4A3 [nucleoplasm]

Stable Identifier

R-HSA-8849149

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Eukaryotic initiation factor 4A-III, IF4A3_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        EIF4A3 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        Core EJC [nucleoplasm] (Homo sapiens)
        
        EIF4A3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38919 EIF4A3

Gene Names

EIF4A3, DDX48, KIAA0111

Chain

chain:1-411, initiator methionine:, chain:2-411

Reference Genes

BioGPS Gene:9775 EIF4A3

COSMIC (genes):EIF4A3 EIF4A3

CTD Gene:9775 EIF4A3

dbSNP Gene:9775 EIF4A3

ENSEMBL:ENSG00000141543 EIF4A3

ENSEMBL_homo_sapiens_GENE:ENSG00000141543.12 EIF4A3

ENSEMBL_homo_sapiens_GENE:ENSG00000291508.1 EIF4A3

HGNC:18683 EIF4A3

KEGG Gene (Homo sapiens):9775 EIF4A3

Monarch:9775 EIF4A3

NCBI Gene:9775 EIF4A3

OMIM:608546 EIF4A3

UCSC:P38919 EIF4A3

Reference Transcript

RefSeq:NM_014740.3 EIF4A3

Other Identifiers

11756176_a_at

16849667

201303_PM_at

201303_at

3773311

3773313

3773314

3773316

3773318

3773321

3773324

3773326

3773327

3773328

3773329

3773332

3773334

3773335

3773336

3773337

3773338

3773339

38031_at

8019046

9775

A_23_P141636

D21853_at

GE57117

GO:0000166

GO:0000184

GO:0000398

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005681

GO:0005730

GO:0005737

GO:0005829

GO:0006364

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008143

GO:0008306

GO:0008380

GO:0010629

GO:0014070

GO:0016020

GO:0016071

GO:0016607

GO:0016787

GO:0016887

GO:0017148

GO:0023052

GO:0030425

GO:0035145

GO:0035368

GO:0035613

GO:0035640

GO:0042254

GO:0043021

GO:0043025

GO:0043226

GO:0045727

GO:0048701

GO:0048856

GO:0050877

GO:0051028

GO:0071006

GO:0071013

GO:0072715

GO:0090394

GO:0098794

GO:0098978

GO:0099578

GO:0140098

GO:0140657

GO:1904570

GO:1990416

GO:1990904

GO:2000622

HMNXSV003023654

ILMN_1667043

PH_hs_0024508

TC17001933.hg

g7661919_3p_at

Participates

as a component of

as an input of

Formation of the Spliceosomal Bact complex (Homo sapiens)

Other forms of this molecule

EIF4A3 [cytosol]

Inferred To

EIF4A3 [nucleoplasm] (Bos taurus)

EIF4A3 [nucleoplasm] (Canis familiaris)

EIF4A3 [nucleoplasm] (Danio rerio)

EIF4A3 [nucleoplasm] (Dictyostelium discoideum)

EIF4A3 [nucleoplasm] (Drosophila melanogaster)

EIF4A3 [nucleoplasm] (Gallus gallus)

EIF4A3 [nucleoplasm] (Mus musculus)

EIF4A3 [nucleoplasm] (Plasmodium falciparum)

EIF4A3 [nucleoplasm] (Rattus norvegicus)

EIF4A3 [nucleoplasm] (Saccharomyces cerevisiae)

EIF4A3 [nucleoplasm] (Schizosaccharomyces pombe)

EIF4A3 [nucleoplasm] (Sus scrofa)

EIF4A3 [nucleoplasm] (Xenopus tropicalis)

eif-4a3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_055555.1

OpenTargets

ENSG00000141543

GeneCards

P38919

HPA

ENSG00000141543-EIF4A3

Ensembl

ENST00000647795, ENSP00000497641, ENST00000649764, ENSP00000497661, ENSG00000141543

PRO

P38919

Pharos - Targets

P38919

Orphanet

22596

HMDB Protein

HMDBP11795

PDB

7W5A, 7ZNJ, 3EX7, 5XJC, 6ICZ, 7W5B, 5YZG, 2XB2, 2J0U, 8C6J, 2HXY, 2J0S, 6YVH, 7W59, 2J0Q, 7A5P, 2HYI, 4C9B, 5MQF, 6QDV

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.98	37
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.947	22
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.938	30
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.883	9
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.815	6
UniProt:Q6PII3 CC174			0.743	5
UniProt:Q92900-2 UPF1			0.725	4
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.718	6
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.69	4
UniProt:Q5C9Z4 NOM1			0.688	4
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.662	7
UniProt:Q9Y5S9-1 RBM8A			0.643	6
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.643	3
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.643	3
UniProt:Q9BY77 POLDIP3	2	POLDIP3 [nucleoplasm] (R-HSA-8850646) POLDIP3 [cytosol] (R-HSA-8850627)	0.623	3
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.597	3
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.597	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.564	2
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.558	4
UniProt:Q96GN5 CDA7L			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q9H8Y1 VRTN			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q6P9H4 CNKR3			0.556	3
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.556	3
UniProt:Q3KNR5 Q3KNR5			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9NY93 DDX56			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P98169 ZXDB			0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:P55039 DRG2	2	3OHK21-DRG2 [cytosol] (R-HSA-9629595) DRG2 [cytosol] (R-HSA-9629597)	0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.536	2
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.528	2
UniProt:Q9Y3X0 CCDC9			0.527	2
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	2
UniProt:Q8N653 LZTR1			0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:Q53F19 NCBP3			0.527	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	6
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	5
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.527	2
UniProt:O00422 SAP18	1	SAP18 [nucleoplasm] (R-HSA-351694)	0.499	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5
UniProt:Q13838 DDX39B	2	DDX39B [cytosol] (R-HSA-9715154) DDX39B [nucleoplasm] (R-HSA-8849139)	0.462	2

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