Dissociation of the SPINK5:KLK5 complex at low pH

Stable Identifier
R-HSA-8849638
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
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Dissociation of the SPINK5:KLK5 complex at low pH
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At low pH, the complex of the D8D9 fragment of SPINK5 (Serine protease inhibitor Kazal-type 5, also known as LEKTI, Lympho-epithelial Kazal-type-related inhibitor), consisting of residues 490 - 624 of the full-length protein, and KLK5 (Kallikrein-5) dissociates, releasing active KLK5 protease. In normal skin, this event occurs extracellularly in upper layers of the skin (Deraison et al. 2007).

Literature References
PubMed ID Title Journal Year
17596512 LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction

Hovnanian, A, Jayakumar, A, Wagberg, F, Besson, C, Deraison, C, Bonnart, C, Leonardsson, G, Brattsand, M, Hachem, JP, Robinson, R, Lopez, F

Mol. Biol. Cell 2007
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Requirements
Orthologous Events
Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)
Dissociation of the SPINK5:KLK5 complex at low pH (Canis familiaris)
Dissociation of the SPINK5:KLK5 complex at low pH (Danio rerio)
Dissociation of the SPINK5:KLK5 complex at low pH (Mus musculus)
Dissociation of the SPINK5:KLK5 complex at low pH (Rattus norvegicus)
Dissociation of the SPINK5:KLK5 complex at low pH (Sus scrofa)
Authored
Jupe, S  (2016-03-10)
Reviewed
Blumenberg, M  (2016-08-12)
Created
D'Eustachio, P  (2015-12-17)
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