SALM1 interacts with and recruits NMDA receptors to early synapses. NMDA receptors are involved in the development of excitatory synapse by interacting with PDZ proteins of the PSD-95 family through its NR2 subunits. SALM1 can directly interact with the extracellular domain of the NR1 subunit of NMDA receptor or indirectly by binding to PSD-95, which may recruit NMDA receptor via the NR2 subunits of NMDA receptors (Wang et al. 2006, Niethammer et al. 1996, Kornau et al. 1995). SALM1 also often localizes with the NR1 subunit of NMDA receptors in hippocampal and cerebellar neurons (Thevenon et al., 2015).