Reactome | PDCL releases folded G-beta from TRiC/CCT

PDCL releases folded G-beta from TRiC/CCT

Stable Identifier

R-HSA-8850527

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PDCL releases folded G-beta from TRiC/CCT

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PDCL (PhLP1) enables completion of folding of G-protein beta subunits 1-4 (GNB1, GNB2, GNB3 and GNB4) by the TRiC/CCT chaperonin, resulting in the release of dimers of PDCL and folded G-protein beta 1-4 (Lukov et al. 2005, Lukov et al. 2006, Howlett et al. 2009, Plimpton et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
19376773	Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity Gray, AJ, Hunter, JM, Howlett, AC, Willardson, BM	J. Biol. Chem.	2009
16717095	Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex Thulin, CD, Lukov, GL, Ludtke, PJ, Hu, T, Carter, MD, Baker, CM, Hackett, RA, Willardson, BM	J. Biol. Chem.	2006
15889144	Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM	EMBO J.	2005
25675501	Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly Makaju, A, Lai, CW, Prince, JT, Carrascosa, JL, Plimpton, RL, Cuellar, J, Valpuesta, JM, Aoba, T, Franklin, S, Willardson, BM, Mathis, AD	Proc. Natl. Acad. Sci. U.S.A.	2015