Reactome | G-protein alpha releases G-protein heterotrimer from PDCL

G-protein alpha releases G-protein heterotrimer from PDCL

Stable Identifier

R-HSA-8850560

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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G-protein alpha releases G-protein heterotrimer from PDCL

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G-protein alpha associates with G-protein beta:gamma dimers bound to PDCL (PhLP1), resulting in release of the G-protein heterotrimer from PDCL co-chaperone (Lukov et al. 2005, Plimpton et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
15889144	Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM	EMBO J.	2005
25675501	Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly Makaju, A, Lai, CW, Prince, JT, Carrascosa, JL, Plimpton, RL, Cuellar, J, Valpuesta, JM, Aoba, T, Franklin, S, Willardson, BM, Mathis, AD	Proc. Natl. Acad. Sci. U.S.A.	2015