Reactome | RNF115 [cytosol]

RNF115 [cytosol]

Stable Identifier

R-HSA-8850904

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="10"E3 ubiquitin-protein ligase RNF115 ecNumber evidence="6"6.3.2.-/ecNumber, RN115_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y4L5 RNF115

Gene Names

RNF115, ZNF364

Chain

initiator methionine:, chain:2-304

Reference Genes

BioGPS Gene:27246 RNF115

COSMIC (genes):RNF115 RNF115

CTD Gene:27246 RNF115

dbSNP Gene:27246 RNF115

ENSEMBL:ENSG00000265491 RNF115

HGNC:18154 RNF115

KEGG:hsa:27246 RNF115

Monarch:27246 RNF115

NCBI Gene:27246 RNF115

OMIM:619535 RNF115

UCSC:Q9Y4L5 RNF115

Reference Transcript

RefSeq:NM_014455.3 RNF115

Other Identifiers

11743013_a_at

16669930

212742_PM_at

212742_at

226468_PM_at

226468_at

2356345

2356346

2356352

2356356

2356357

2356358

2356359

2356361

2356363

2356364

2356365

2356366

2356367

2356368

2356398

2356406

2356408

2356410

2356411

2356413

2356415

2356417

2356419

2356420

2356422

239383_PM_at

239383_at

243976_PM_at

243976_at

27246

32129_at

33111_at

43767_at

47775_at

52913_at

7904830

92093_i_at

92095_r_at

A_14_P102237

A_14_P127504

A_19_P00806976

A_23_P161064

A_24_P560909

GE486619

GE56319

GE906920

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0016567

GO:0016740

GO:0034122

GO:0042059

GO:0043162

GO:0043226

GO:0046872

GO:0051865

GO:0061630

GO:0070534

GO:0070936

GO:0070979

GO:0140096

HMNXSV003003045

Hs.111364.0.A1_3p_at

Hs.16537.0.A1_3p_at

Hs.62909.0.A1_3p_at

ILMN_1811997

PH_hs_0001530

PH_hs_0003959

PH_hs_0006113

TC01001098.hg

Participates

as a member of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

rnf-126 [cytosol] (Caenorhabditis elegans)

rnf115 [cytosol] (Xenopus tropicalis)

RNF115 [cytosol] (Bos taurus)

RNF115 [cytosol] (Dictyostelium discoideum)

RNF115 [cytosol] (Sus scrofa)

Rnf115 [cytosol] (Mus musculus)

Rnf115 [cytosol] (Rattus norvegicus)

rnf115a [cytosol] (Danio rerio)

Iru [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000463650, ENST00000582693, ENSG00000265491

OpenTargets

ENSG00000265491

GeneCards

RNF115

HPA

ENSG00000265491-RNF115

PRO

Q9Y4L5

Pharos - Targets

Q9Y4L5

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	4	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) Ub-C85-UBE2D1 [nucleoplasm] (R-HSA-8937534)	0.83	12
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.781	11
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.544	2

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