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MYLIP [cytosol]
Stable Identifier
R-HSA-8850908
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase MYLIP ecNumber6.3.2.-/ecNumber, MYLIP_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3
Expand all
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake (Homo sapiens)
Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WY64 MYLIP
Gene Names
MYLIP, BZF1, IDOL, BM-023, PP5242
Chain
chain:1-445
Reference Genes
BioGPS Gene:29116 MYLIP
COSMIC (genes):MYLIP MYLIP
CTD Gene:29116 MYLIP
dbSNP Gene:29116 MYLIP
ENSEMBL:ENSG00000007944 MYLIP
ENSEMBL_homo_sapiens_GENE:ENSG00000007944.15 MYLIP
HGNC:21155 MYLIP
KEGG Gene (Homo sapiens):29116 MYLIP
Monarch:29116 MYLIP
NCBI Gene:29116 MYLIP
OMIM:610082 MYLIP
UCSC:Q8WY64 MYLIP
Reference Transcript
RefSeq:NM_013262.3 MYLIP
Other Identifiers
11718006_a_at
11718007_a_at
11757972_s_at
17005077
220319_PM_s_at
220319_s_at
223129_PM_x_at
223129_x_at
223130_PM_s_at
223130_s_at
228098_PM_s_at
228098_s_at
2896485
2896486
2896488
2896497
2896498
2896499
2896500
2896501
2896503
2896507
2896508
2896512
2896513
2896514
2896515
2896516
29116
49005_at
8117020
A_14_P108430
A_14_P116038
A_14_P202465
A_23_P31041
A_24_P917123
A_33_P3255914
GE62520
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006511
GO:0007399
GO:0008092
GO:0010977
GO:0010989
GO:0016020
GO:0016567
GO:0016740
GO:0030154
GO:0030163
GO:0031648
GO:0032803
GO:0036211
GO:0042632
GO:0043226
GO:0045732
GO:0046872
GO:0048856
GO:0061630
GO:0140096
HMNXSV003002678
Hs.20072.1.S1_3p_a_at
ILMN_1656111
PH_hs_0025924
TC06000108.hg
g9437508_3p_a_at
Participates
as an output of
Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)
as a component of
MYLIP dimer [cytosol] (Homo sapiens)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
mylipa [cytosol]
(Danio rerio)
MYLIP [cytosol]
(Bos taurus)
MYLIP [cytosol]
(Canis familiaris)
MYLIP [cytosol]
(Gallus gallus)
MYLIP [cytosol]
(Mus musculus)
MYLIP [cytosol]
(Rattus norvegicus)
MYLIP [cytosol]
(Sus scrofa)
mylip [cytosol]
(Xenopus tropicalis)
dnr1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_037394.2
OpenTargets
ENSG00000007944
IntEnz
2.3.2.27
GeneCards
Q8WY64
HPA
ENSG00000007944-MYLIP
Ensembl
ENST00000356840
,
ENSP00000349298
,
ENSG00000007944
PRO
Q8WY64
Pharos - Targets
Q8WY64
HMDB Protein
HMDBP09279
PDB
6QLZ
,
2YHN
,
6QLY
,
2YHO
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86WV8 Q86WV8
0.718
6
UniProt:Q8N448 LNX2
0.668
4
UniProt:Q8WWW0 RASF5
0.666
4
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.556
3
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.556
3
UniProt:A0A6Q8PF08 A0A6Q8PF08
0.556
3
UniProt:Q99592 ZBT18
0.556
3
UniProt:Q9Y3Q8 T22D4
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:Q9UMF0 ICAM5
1
ICAM5 [plasma membrane]
(R-HSA-197684)
0.556
3
UniProt:P0CG21 NHLC4
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:Q03989 ARI5A
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q5T7N3 KANK4
0.556
3
UniProt:Q86UR1-2 NOXA1
0.556
5
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:Q9BWG6 SCNM1
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q7Z4V0 ZN438
0.556
3
UniProt:Q6NSM0 Q6NSM0
0.556
6
UniProt:P55771 PAX9
0.556
6
UniProt:O14901 KLF11
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q6PD62 CTR9
1
CTR9 [nucleoplasm]
(R-HSA-8866694)
0.527
2
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.527
2
UniProt:Q8IWB7 WDFY1
0.527
2
UniProt:Q9Y2B0 CNPY2
0.508
3
UniProt:Q9NSY1 BMP2K
0.488
2
UniProt:Q9UN19 DAPP1
2
p-Y139-DAPP1 [plasma membrane]
(R-HSA-1112650)
DAPP1 [cytosol]
(R-HSA-197950)
0.488
2
UniProt:P46108-2 CRK
0.488
2
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