Reactome | NTPDase2 hydrolyzes nucleoside triphosphates

NTPDase2 hydrolyzes nucleoside triphosphates

Stable Identifier

R-HSA-8851089

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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NTPDase2 hydrolyzes nucleoside triphosphates

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NTPDase2 (CD39L1), encoded by the ENTPD2 gene, is an ectonucleoside triphosphate diphosphohydrolase that is expressed at the plasma membrane where it hydrolyzes extracellular nucleoside triphosphates (ATP, GTP, CTP, ITP, UTP) to the respective nucleoside diphosphate (ADP, GDP, CDP, IDP, UDP) in the presence of Ca2+ of Mg2+ ions. NTPDase2 is only marginally active in hydrolyzing nucleoside diphosphates, such as ADP and UDP (Kegel et al. 1997, Kirley et al. 1997, Mateo et al. 1999). The alpha splicing isoform of NTPDase2 is expressed at the plasma membrane, while beta and gamma isoforms are expressed in the endoplasmic reticulum (Mateo et al. 2003). NTPDase2 may oligomerize and the oligomerization state may affect substrate specificity (Failer et al. 2003).

NTPDase2 may contribute to vascular hemostasis by exerting an opposing role to NTPDase1 (Sévigny et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8995405	Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase. Homology with the lymphoid cell activation antigen CD39 Kirley, TL	J. Biol. Chem.	1997
11929769	Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation Qawi, I, Sévigny, J, Imai, M, Robson, SC, Guckelberger, O, Sundberg, C, Braun, N, Zimmermann, H, Csizmadia, E	Blood	2002
9364474	An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain Braun, N, Heine, P, Kegel, B, Zimmermann, H, Maliszewski, CR	Neuropharmacology	1997
12888562	Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme Kreda, S, Boyer, JL, Mateo, J, Harden, TK, Henry, CE	J. Biol. Chem.	2003
10510450	Functional expression of a cDNA encoding a human ecto-ATPase Boyer, JL, Harden, TK, Mateo, J	Br. J. Pharmacol.	1999
12694193	Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes Schmalzing, G, Aschrafi, A, Failer, BU, Zimmermann, H	Eur. J. Biochem.	2003