NTPDase6 hydrolyzes nucleoside diphosphates

Stable Identifier
Reaction [transition]
Homo sapiens
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NTPDase6 (CD39L2), encoded by the ENTPD6 gene, is an ectonucleotide phosphatase of the E-NTPDase family that can be secreted (Yeung et al. 2000). Secretion involves the removal of the first 77 amino acids at the N-terminus by an unknown peptidase. Secreted NTPDase6 hydrolyzes nucleoside diphosphates GDP, IDP and, less efficiently, UDP and CDP to nucleoside monophosphates GMP, IMP, UMP and CMP, respectively. Secreted NTPDase6 hydrolyzes ADP to AMP and nucleoside triphosphates GTP, ITP, UTP and CTP to corresponding nucleoside diphosphates with very low efficacy (Hicks-Berger et al. 2000, Yeung et al. 2000, Ivanenkov et al. 2003). NTPDase6 requires Ca2+ or Mg2+ for catalytic activity (Hicks-Berger et al. 2000, Ivanenkov et al. 2003).

NTPDase6 may also be able to function as a membrane-bound enzyme, but its catalytic rate is very low and accounts for up to 10% of NTPDase6 activity (Hicks-Berger et al. 2000).

Literature References
PubMed ID Title Journal Year
14529283 Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function

Ivanenkov, VV, Kirley, TL, Murphy-Piedmonte, DM

Biochemistry 2003
11041856 CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart

Yeung, G, Ford, JE, McGowan, DW, Mulero, JJ, Bajwa, SS

Biochemistry 2000
10948193 Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2)

Frischauf, AM, Hicks-Berger, CA, Kirley, TL, Chadwick, BP

J. Biol. Chem. 2000
Catalyst Activity

nucleoside-diphosphatase activity of NTPDase6:Ca2+,Mg2+ [extracellular region]

Orthologous Events
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