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LNX1 [cytosol]
Stable Identifier
R-HSA-8851641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase LNX ecNumber6.3.2.-/ecNumber, LNX1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TBB1 LNX1
Gene Names
LNX1, LNX, PDZRN2, UNQ574/PRO1136
Chain
chain:1-728
Reference Genes
BioGPS Gene:84708 LNX1
COSMIC (genes):LNX1 LNX1
CTD Gene:84708 LNX1
dbSNP Gene:84708 LNX1
ENSEMBL:ENSG00000072201 LNX1
ENSEMBL_homo_sapiens_GENE:ENSG00000072201.14 LNX1
HGNC:6657 LNX1
KEGG Gene (Homo sapiens):84708 LNX1
Monarch:84708 LNX1
NCBI Gene:84708 LNX1
OMIM:609732 LNX1
UCSC:Q8TBB1 LNX1
Reference Transcript
RefSeq:NM_001126328.2 LNX1
RefSeq:NM_032622.2 LNX1
RefSeq:XM_005265785.4 LNX1
RefSeq:XM_017008776.1 LNX1
Other Identifiers
11730250_a_at
11730251_x_at
11750800_a_at
11759021_at
16975971
223611_PM_s_at
223611_s_at
223612_PM_s_at
223612_s_at
2769349
2769350
2769351
2769352
2769354
2769355
2769356
2769358
2769359
2769361
2769362
2769363
2769364
2769365
2769370
2769371
2769372
2769373
2769376
2769377
2769378
2769379
2769403
58454_at
8100362
84708
92105_s_at
A_23_P213137
A_24_P54900
GE83457
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0006511
GO:0016567
GO:0016740
GO:0030163
GO:0030165
GO:0036211
GO:0042802
GO:0046872
GO:0140096
HMNXSV003041278
Hs.66295.1.A1_3p_a_at
ILMN_1713841
PH_hs_0004051
TC04001199.hg
g13183072_3p_a_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Patj [cytosol]
(Drosophila melanogaster)
lnx1 [cytosol]
(Xenopus tropicalis)
LNX1 [cytosol]
(Bos taurus)
LNX1 [cytosol]
(Caenorhabditis elegans)
LNX1 [cytosol]
(Canis familiaris)
LNX1 [cytosol]
(Gallus gallus)
LNX1 [cytosol]
(Sus scrofa)
Homologues of LNX1 [cytosol]
(Caenorhabditis elegans)
Homologues of LNX1 [cytosol]
(Drosophila melanogaster)
mpz-1 [cytosol]
(Caenorhabditis elegans)
Lnx1 [cytosol]
(Mus musculus)
Lnx1 [cytosol]
(Rattus norvegicus)
a [cytosol]
(Drosophila melanogaster)
frm-5.2 [cytosol]
(Caenorhabditis elegans)
inaD [cytosol]
(Drosophila melanogaster)
frm-5.1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001119800.1
,
XP_005265842.1
,
NP_116011.2
,
XP_016864265.1
OpenTargets
ENSG00000072201
GeneCards
Q8TBB1
HPA
ENSG00000072201-LNX1
Ensembl
ENST00000263925
,
ENSP00000302879
,
ENSG00000072201
,
ENSP00000263925
,
ENST00000306888
PRO
Q8TBB1
Pharos - Targets
Q8TBB1
HMDB Protein
HMDBP09319
PDB
3B76
,
5H7S
,
5H7R
Interactors (82)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.83
8
UniProt:Q96GX9 APIP
1
APIP [cytosol]
(R-HSA-1237171)
0.83
11
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.781
7
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.781
7
UniProt:P49247 RPIA
2
RPIA [cytosol]
(R-HSA-71304)
RPIA A61V [cytosol]
(R-HSA-5660009)
0.742
5
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.742
5
UniProt:O75553 DAB1
2
DAB1 [cytosol]
(R-HSA-8855236)
p-Y198,220,232-DAB1 [cytosol]
(R-HSA-8855227)
0.742
5
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.742
5
UniProt:O75771 RAD51D
1
RAD51D [nucleoplasm]
(R-HSA-216920)
0.718
6
UniProt:O95848 NUDT14
1
NUDT14 [cytosol]
(R-HSA-6809220)
0.718
8
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.718
6
UniProt:Q9Y316 MEMO1
1
MEMO1 [cytosol]
(R-HSA-6785630)
0.718
6
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.696
7
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.666
4
UniProt:Q8WZA1 POMGNT1
6
POMGNT1 P493R [Golgi membrane]
(R-HSA-5617048)
POMGNT1 W475* [Golgi membrane]
(R-HSA-5617097)
POMGNT1 R63* [Golgi membrane]
(R-HSA-5617033)
POMGNT1 R605Vfs*29 [Golgi membrane]
(R-HSA-5617081)
POMGNT1 S550N [Golgi membrane]
(R-HSA-5617094)
POMGNT1 [Golgi membrane]
(R-HSA-5617040)
0.666
4
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.666
4
UniProt:Q8WXB1 METTL21A
1
METTL21A [nucleoplasm]
(R-HSA-8876682)
0.666
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.666
4
UniProt:Q15056 EIF4H
1
EIF4H [cytosol]
(R-HSA-72591)
0.666
4
UniProt:Q13370 PDE3B
2
PDE3B [cytosol]
(R-HSA-162348)
p-S295-PDE3B [cytosol]
(R-HSA-162419)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.556
3
UniProt:Q9H2G4 TSPYL2
1
TSPYL2 [nucleoplasm]
(R-HSA-535540)
0.556
3
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.556
3
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q9H1K1 ISCU
1
ISCU [cytosol]
(R-HSA-9771680)
0.556
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.556
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.556
3
UniProt:Q9Y3M2 CBY1
3
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.556
3
UniProt:P11086 PNMT
1
PNMT [cytosol]
(R-HSA-209831)
0.556
3
UniProt:P62306 SNRPF
2
SNRPF [nucleoplasm]
(R-HSA-71907)
SNRPF [cytosol]
(R-HSA-191852)
0.556
3
UniProt:P49327 FASN
3
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-54659)
FASN [cytosol]
(R-HSA-199233)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:O14561 NDUFAB1
3
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
5
UniProt:Q9NWX6 THG1L
1
THG1L [cytosol]
(R-HSA-6782438)
0.556
3
UniProt:Q9NS75 CYSLTR2
1
CYSLTR2 [plasma membrane]
(R-HSA-416399)
0.556
3
UniProt:P52597 HNRNPF
2
HNRNPF [plasma membrane]
(R-HSA-8950714)
HNRNPF [nucleoplasm]
(R-HSA-71937)
0.556
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.556
3
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.556
5
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
PPIA [extracellular region]
(R-HSA-173646)
0.556
3
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q9UL46 PSME2
2
PSME2 [nucleoplasm]
(R-HSA-174350)
PSME2 [cytosol]
(R-HSA-68814)
0.556
3
UniProt:P12931 SRC
6
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.556
6
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.556
3
UniProt:Q53H54 TRMT12
1
TRMT12 [cytoplasm]
(R-HSA-6782860)
0.556
3
UniProt:Q96G04 EEF2KMT
1
EEF2KMT [cytosol]
(R-HSA-8876690)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
0.556
3
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:Q86TI0 TBC1D1
2
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
0.556
3
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
UniProt:P50458 LHX2
1
LHX2 [nucleoplasm]
(R-HSA-9011100)
0.556
3
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.556
3
UniProt:Q6UWP7 LCLAT1
1
LCLAT1 [endoplasmic reticulum membrane]
(R-HSA-1498783)
0.556
3
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.553
2
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.553
2
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
4
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:P52333 JAK3
6
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
JAK3 [endosome]
(R-HSA-8983184)
p-JAK3 [cytosol]
(R-HSA-8982856)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
JAK3 [cytosol]
(R-HSA-451893)
0.488
2
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.463
2
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