Reactome | KLHL11 [cytosol]

KLHL11 [cytosol]

Stable Identifier

R-HSA-8851653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch-like protein 11, KLH11_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVR0 KLHL11

Gene Names

KLHL11

Chain

signal peptide:1-15, chain:16-708

Reference Genes

BioGPS Gene:55175 KLHL11

COSMIC (genes):KLHL11 KLHL11

CTD Gene:55175 KLHL11

dbSNP Gene:55175 KLHL11

ENSEMBL:ENSG00000178502 KLHL11

ENSEMBL_homo_sapiens_GENE:ENSG00000178502.6 KLHL11

HGNC:19008 KLHL11

KEGG Gene (Homo sapiens):55175 KLHL11

Monarch:55175 KLHL11

NCBI Gene:55175 KLHL11

OMIM:619078 KLHL11

UCSC:Q9NVR0 KLHL11

Reference Transcript

RefSeq:NM_018143.2 KLHL11

Other Identifiers

11733351_at

16844927

16844929

220657_PM_at

220657_at

226883_PM_at

226883_at

3757424

3757425

3757426

3757427

3757428

3757429

3757430

3757432

53818_at

55175

8015456

A_23_P55388

A_24_P22657

GE783915

GE82309

GO:0005515

GO:0005829

HMNXSV003044070

Hs.13268.0.A1_3p_at

ILMN_1752416

ILMN_2049423

PH_hs_0021999

PH_hs_0037469

TC17001519.hg

g8922527_3p_at

p6823

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

klhl11 [cytosol] (Xenopus tropicalis)

kel-1 [cytosol] (Caenorhabditis elegans)

KLHL11 [cytosol] (Bos taurus)

KLHL11 [cytosol] (Canis familiaris)

KLHL11 [cytosol] (Dictyostelium discoideum)

KLHL11 [cytosol] (Gallus gallus)

KLHL11 [cytosol] (Plasmodium falciparum)

KLHL11 [cytosol] (Sus scrofa)

wu:fd21e01 [cytosol] (Danio rerio)

kel [cytosol] (Drosophila melanogaster)

Klhl11 [cytosol] (Mus musculus)

Klhl11 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_060613.1

OpenTargets

ENSG00000178502

HPA

ENSG00000178502-KLHL11

GeneCards

Q9NVR0

Ensembl

ENST00000319121, ENSP00000314608, ENSG00000178502

PRO

Q9NVR0

Pharos - Targets

Q9NVR0

PDB

3I3N, 4AP2, 4APF

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