Reactome | GPR183 [plasma membrane]

GPR183 [plasma membrane]

Stable Identifier

R-HSA-8851676

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein coupled receptor 183, GP183_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8WVM7 STAG1

Expand all

General

GPR183 (originally called EBI2) binds the oxysterol 7alpha,25-dihydroxycholesterol (7a,25-OHC) (Hannedouche et al. 2011, Liu et al. 2011). GPR183 is believed to played a key role in regulating B cell migration and responses (Gatto et al. 2009, Pereira et al. 2009, Yi et al. 2012, Sun & Liu 2015). It signals via Gi (Rosenkilde et al. 2006).

External Reference Information

External Reference

UniProt:P32249 GPR183

Gene Names

GPR183, EBI2

Chain

chain:1-361

Reference Genes

BioGPS Gene:1880 GPR183

COSMIC (genes):GPR183 GPR183

CTD Gene:1880 GPR183

dbSNP Gene:1880 GPR183

ENSEMBL:ENSG00000169508 GPR183

HGNC:3128 GPR183

KEGG:hsa:1880 GPR183

Monarch:1880 GPR183

NCBI Gene:1880 GPR183

OMIM:605741 GPR183

UCSC:P32249 GPR183

Reference Transcript

Other Identifiers

11727428_at

11758555_s_at

16780592

1880

205419_PM_at

205419_at

3522663

3522664

3522665

3522669

7972557

931_at

A_23_P25566

GE57589

GO:0002250

GO:0002312

GO:0002313

GO:0002376

GO:0002407

GO:0004930

GO:0005886

GO:0006955

GO:0006959

GO:0007186

GO:0008142

GO:0008289

GO:0010818

GO:0016020

GO:0030154

GO:0030316

GO:0030595

GO:0030890

GO:0036145

GO:0048870

GO:0060089

GO:0060326

GO:0061470

GO:0070374

GO:2000458

HMNXSV003030157

ILMN_1798706

ILMN_2168217

L08177_at

PH_hs_0000092

PH_hs_0040414

TC13000829.hg

g4826705_3p_at

g4826705_3p_x_at

Participates

as an input of

GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)

as a component of

GPR183:7alpha,25-dihydroxycholesterol [plasma membrane] (Homo sapiens)

Inferred To

GPR183 [plasma membrane] (Bos taurus)

GPR183 [plasma membrane] (Canis familiaris)

GPR183 [plasma membrane] (Gallus gallus)

GPR183 [plasma membrane] (Mus musculus)

GPR183 [plasma membrane] (Rattus norvegicus)

GPR183 [plasma membrane] (Sus scrofa)

gpr183.2 [plasma membrane] (Xenopus tropicalis)

gpr183a [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_004942.1, XP_016875894.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000376414, ENSP00000365596

OpenTargets

ENSG00000169508

HPA

ENSG00000169508-GPR183

ZINC - Substances

GP183_HUMAN

ZINC target

P32249

PRO

P32249

Pharos - Targets

P32249

ZINC - Predictions - Purchasable

GP183_HUMAN

PDB

7TUY, 7TUZ

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31431 SDC4	20	HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674) HS(5)-SDC4 [plasma membrane] (R-HSA-2076635) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064249) SDC4 [Golgi lumen] (R-HSA-2054111) Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064100) GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen] (R-HSA-2064067) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374)	0.527	2
UniProt:Q63HK5 TSH3			0.527	3
UniProt:Q53FV1 ORMDL2	1	ORMDL2 [endoplasmic reticulum membrane] (R-HSA-8865591)	0.527	2
UniProt:Q6PL24 TMED8			0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	4
UniProt:O75487 GPC4	20	HS(4)-GPC4 [plasma membrane] (R-HSA-2076638) HS(6)-GPC4 [plasma membrane] (R-HSA-2076677) HS(2)-GPC4 [plasma membrane] (R-HSA-2076662) HS(1)-GPC4 [plasma membrane] (R-HSA-2076673) HS(3)-GPC4 [plasma membrane] (R-HSA-2076697) HS(5)-GPC4 [plasma membrane] (R-HSA-2076658) XylS-GPC4 [Golgi lumen] (R-HSA-2064173) Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064060) GPC4 [Golgi lumen] (R-HSA-2054108) Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064030) GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen] (R-HSA-2064215) HS(3)-GPC4 [Golgi lumen] (R-HSA-2076439) HS(4)-GPC4 [Golgi lumen] (R-HSA-2076368) HS(2)-GPC4 [Golgi lumen] (R-HSA-2076336) HS(1)-GPC4 [Golgi lumen] (R-HSA-2076401) Heparan(4)-GPC4 [Golgi lumen] (R-HSA-2076440) Heparan(3)-GPC4 [Golgi lumen] (R-HSA-2076612) Heparan(2)-GPC4 [Golgi lumen] (R-HSA-2076555) Heparan(1)-GPC4 [Golgi lumen] (R-HSA-2076560) Heparan-GPC4 [Golgi lumen] (R-HSA-2076475)	0.527	3
UniProt:Q52LW3 ARHGAP29	1	ARHGAP29 [cytosol] (R-HSA-195159)	0.527	2
UniProt:P51654 GPC3	20	HS(4)-GPC3 [plasma membrane] (R-HSA-2076637) HS(6)-GPC3 [plasma membrane] (R-HSA-2076656) HS(2)-GPC3 [plasma membrane] (R-HSA-2076622) HS(1)-GPC3 [plasma membrane] (R-HSA-2076660) HS(3)-GPC3 [plasma membrane] (R-HSA-2076650) HS(5)-GPC3 [plasma membrane] (R-HSA-2076669) GPC3 [endoplasmic reticulum lumen] (R-HSA-8956735) p-GPC3 [endoplasmic reticulum lumen] (R-HSA-8956894) XylS-GPC3(25-?) [Golgi lumen] (R-HSA-2064021) Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2064202) GPC3(25-?) [Golgi lumen] (R-HSA-2054100) Gal-Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2063987) GlcA-Gal-Gal-Xyl-GPC3 [Golgi lumen] (R-HSA-2064012) HS(3)-GPC3 [Golgi lumen] (R-HSA-2076507) HS(4)-GPC3 [Golgi lumen] (R-HSA-2076550) HS(2)-GPC3 [Golgi lumen] (R-HSA-2076413) HS(1)-GPC3 [Golgi lumen] (R-HSA-2076471) Heparan(4)-GPC3 [Golgi lumen] (R-HSA-2076377) Heparan(3)-GPC3 [Golgi lumen] (R-HSA-2076311) Heparan(2)-GPC3 [Golgi lumen] (R-HSA-2076409)	0.527	3
UniProt:Q9NR50 EIF2B3	1	EIF2B3 [cytosol] (R-HSA-72525)	0.527	4
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.527	3
UniProt:Q9Y625 GPC6	20	HS(4)-GPC6 [plasma membrane] (R-HSA-2076651) HS(6)-GPC6 [plasma membrane] (R-HSA-2076682) HS(2)-GPC6 [plasma membrane] (R-HSA-2076687) HS(1)-GPC6 [plasma membrane] (R-HSA-2076630) HS(3)-GPC6 [plasma membrane] (R-HSA-2076664) HS(5)-GPC6 [plasma membrane] (R-HSA-2076695) XylS-GPC6 [Golgi lumen] (R-HSA-2064057) Gal-Xyl-GPC6 [Golgi lumen] (R-HSA-2064104) GPC6 [Golgi lumen] (R-HSA-2054099) Gal-Gal-Xyl-GPC6 [Golgi lumen] (R-HSA-2064114) GlcA-Gal-Gal-Xyl-GPC6 [Golgi lumen] (R-HSA-2064250) HS(3)-GPC6 [Golgi lumen] (R-HSA-2076511) HS(4)-GPC6 [Golgi lumen] (R-HSA-2076590) HS(2)-GPC6 [Golgi lumen] (R-HSA-2076324) HS(1)-GPC6 [Golgi lumen] (R-HSA-2076402) Heparan(4)-GPC6 [Golgi lumen] (R-HSA-2076549) Heparan(3)-GPC6 [Golgi lumen] (R-HSA-2076497) Heparan(2)-GPC6 [Golgi lumen] (R-HSA-2076415) Heparan(1)-GPC6 [Golgi lumen] (R-HSA-2076378) Heparan-GPC6 [Golgi lumen] (R-HSA-2076534)	0.527	3
UniProt:Q8IYR6 TEFF1			0.527	2
UniProt:Q13144 EIF2B5	1	EIF2B5 [cytosol] (R-HSA-72523)	0.527	4
UniProt:Q14232 EIF2B1	1	EIF2B1 [cytosol] (R-HSA-72517)	0.527	4
UniProt:P35052 GPC1	20	HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648) GPC1 [plasma membrane] (R-HSA-425952) XylS-GPC1 [Golgi lumen] (R-HSA-2064041) Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064076) GPC1 [Golgi lumen] (R-HSA-2054106) Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064144) GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064189) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340) HS(4)-GPC1 [Golgi lumen] (R-HSA-2076502) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476)	0.527	4
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.527	3
UniProt:Q9HCG8 CWC22	1	CWC22 [nucleoplasm] (R-HSA-8865956)	0.527	2
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.527	3

Cite Us!