Reactome | SHC1-2 bound to MET recruits GRB2:SOS1

SHC1-2 bound to MET recruits GRB2:SOS1

Stable Identifier

R-HSA-8851900

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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SHC1 splicing isoform 2 (SHC1-2) phosphorylated by MET on tyrosine residue Y317 recruits the GRB2:SOS1 complex to the activated MET receptor (Pelicci et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7731718	The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein Bardelli, A, Zhen, Z, Waterfield, MD, Lanfrancone, L, Salcini, AE, Ponzetto, C, Giordano, S, Pelicci, G, Pelicci, PG, Panayotou, G	Oncogene	1995