Activated MET binds GAB1

Stable Identifier
R-HSA-8851908
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activated MET binds GAB1
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The adapter protein GAB1 can directly bind to phosphorylated MET receptor via its MET binding domain (MBD) (Schaeper et al. 2000, Lock et al. 2003).
Literature References
PubMed ID Title Journal Year
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Kempkes, B, Fuchs, KP, Birchmeier, W, Sachs, M, Gehring, NH, Schaeper, U

J. Cell Biol. 2000
12766170 Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

Saucier, C, Lock, LS, Park, M, Frigault, MM

J Biol Chem 2003
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Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)
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