Reactome | Activated MET binds GAB1 and GRB2

Activated MET binds GAB1 and GRB2

Stable Identifier

R-HSA-8851919

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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While GAB1 can bind activated MET receptor directly, the presence of GRB2 results in a more stable association between GAB1 and MET (Weidner et al. 1996, Schaeper et al. 2000, Lock et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses Kempkes, B, Fuchs, KP, Birchmeier, W, Sachs, M, Gehring, NH, Schaeper, U	J. Cell Biol.	2000
8906793	Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis Brinkmann, V, Behrens, J, Birchmeier, W, Weidner, KM, Sachs, M, Di Cesare, S	Nature	1996
12766170	Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain Saucier, C, Lock, LS, Park, M, Frigault, MM	J Biol Chem	2003