Phosphorylated GAB1 recruits PI3K to MET

Stable Identifier
R-HSA-8851954
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylated GAB1 recruits PI3K to MET
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Phosphorylated tyrosine residues Y447, Y472 and Y589 of GAB1 are docking sites for the regulatory subunit PIK3R1 of the phosphatidyl inositol-3 kinase (PI3K) complex (Rodrigues et al. 2000). GAB1, phosphorylated by MET, thus recruits PI3K to activated MET (Schaeper et al. 2000).
Literature References
PubMed ID Title Journal Year
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Kempkes, B, Fuchs, KP, Birchmeier, W, Sachs, M, Gehring, NH, Schaeper, U

J. Cell Biol. 2000
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Falasca, M, Rodrigues, GA, Schlessinger, J, Ong, SH, Zhang, Z

Mol Cell Biol 2000
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Orthologous Events
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Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)
Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)
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