Reactome | CDC34 [nucleoplasm]

CDC34 [nucleoplasm]

Stable Identifier

R-HSA-8852125

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 R1 ecNumber evidence="14 19 24 25"2.3.2.23/ecNumber, UB2R1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        CDC34 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49427 CDC34

Gene Names

CDC34, UBCH3, UBE2R1

Chain

chain:1-236

Reference Genes

BioGPS Gene:997 CDC34

COSMIC (genes):CDC34 CDC34

CTD Gene:997 CDC34

dbSNP Gene:997 CDC34

ENSEMBL:ENSG00000099804 CDC34

ENSEMBL_homo_sapiens_GENE:ENSG00000099804.9 CDC34

HGNC:1734 CDC34

KEGG Gene (Homo sapiens):997 CDC34

Monarch:997 CDC34

NCBI Gene:997 CDC34

OMIM:116948 CDC34

UCSC:P49427 CDC34

Reference Transcript

RefSeq:NM_004359.1 CDC34

Other Identifiers

11716983_at

11758296_s_at

1273_r_at

1274_s_at

16856187

212540_PM_at

212540_at

3814979

3814980

3814981

3814982

3814984

3814988

3814994

3814995

3814996

8023968

997

A_24_P177025

GE57676

GO:0000082

GO:0000166

GO:0000209

GO:0000278

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006260

GO:0006270

GO:0006511

GO:0007049

GO:0012501

GO:0016567

GO:0016607

GO:0016740

GO:0019787

GO:0023052

GO:0030163

GO:0032446

GO:0035458

GO:0036211

GO:0043161

GO:0043226

GO:0043525

GO:0043951

GO:0061631

GO:0070848

GO:0070936

GO:0090261

GO:0140096

HMNXSV003018337

HMNXSV003048812

Hs.76932.0.S1_3p_at

Hs.76932.0.S1_3p_x_at

ILMN_1713006

L22005_at

PH_hs_0019786

TC19000007.hg

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-C93-CDC34 [cytosol]

Ub-C93-CDC34 [nucleoplasm]

CDC34 [cytosol]

Inferred To

cdc34 [nucleoplasm] (Xenopus tropicalis)

CDC34 [nucleoplasm] (Bos taurus)

CDC34 [nucleoplasm] (Canis familiaris)

CDC34 [nucleoplasm] (Dictyostelium discoideum)

CDC34 [nucleoplasm] (Gallus gallus)

CDC34 [nucleoplasm] (Plasmodium falciparum)

CDC34 [nucleoplasm] (Saccharomyces cerevisiae)

CDC34 [nucleoplasm] (Sus scrofa)

ubc-3 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CDC34 [nucleoplasm] (Danio rerio)

Homologues of CDC34 [nucleoplasm] (Dictyostelium discoideum)

Homologues of CDC34 [nucleoplasm] (Plasmodium falciparum)

cdc34b [nucleoplasm] (Danio rerio)

ubc15 [nucleoplasm] (Schizosaccharomyces pombe)

Cdc34 [nucleoplasm] (Mus musculus)

Cdc34 [nucleoplasm] (Rattus norvegicus)

cdc34a [nucleoplasm] (Danio rerio)

ubcC [nucleoplasm] (Dictyostelium discoideum)

Dmel\CG7656 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_004350.1

OpenTargets

ENSG00000099804

IntEnz

2.3.2.24

HPA

ENSG00000099804-CDC34

GeneCards

P49427

Ensembl

ENSP00000215574, ENST00000215574, ENSG00000099804

PRO

P49427

Pharos - Targets

P49427

HMDB Protein

HMDBP11991

PDB

2OB4, 8RX0, 3RZ3, 4MDK, 7M2K

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.734	6
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	3
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.544	3

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