Reactome | PTPN22 [cytosol]

PTPN22 [cytosol]

Stable Identifier

R-HSA-8852205

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 22, LYP, Lymphoid phosphatase, PEST-domain phosphatase, PEP, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PTPN8

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y2R2 PTPN22

Gene Names

PTPN22, PTPN8

Chain

chain:1-807

Reference Genes

BioGPS Gene:26191 PTPN22

COSMIC (genes):PTPN22 PTPN22

CTD Gene:26191 PTPN22

dbSNP Gene:26191 PTPN22

ENSEMBL:ENSG00000134242 PTPN22

ENSEMBL_homo_sapiens_GENE:ENSG00000134242.16 PTPN22

HGNC:9652 PTPN22

KEGG Gene (Homo sapiens):26191 PTPN22

Monarch:26191 PTPN22

NCBI Gene:26191 PTPN22

OMIM:600716 PTPN22

UCSC:Q9Y2R2 PTPN22

Reference Transcript

Other Identifiers

11731972_a_at

206060_PM_s_at

206060_s_at

236539_PM_at

236539_at

2428793

2428795

2428797

2428798

2428799

2428800

2428823

2428826

2428827

2428828

2428829

2428831

2428832

26191

36808_at

60604_at

A_33_P3241984

GO:0002230

GO:0002376

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006470

GO:0006629

GO:0006914

GO:0007155

GO:0009898

GO:0010507

GO:0010628

GO:0010629

GO:0016311

GO:0016787

GO:0016791

GO:0017124

GO:0019900

GO:0023052

GO:0030154

GO:0030217

GO:0031625

GO:0031663

GO:0032481

GO:0032496

GO:0032715

GO:0032717

GO:0032720

GO:0032729

GO:0032817

GO:0034141

GO:0034145

GO:0034157

GO:0034165

GO:0035644

GO:0036211

GO:0043226

GO:0043229

GO:0043508

GO:0045088

GO:0048471

GO:0048856

GO:0050852

GO:0050855

GO:0050856

GO:0050860

GO:0050868

GO:0065003

GO:0070374

GO:0070433

GO:0071225

GO:0071663

GO:0098542

GO:0140096

GO:1900227

GO:1901222

GO:1902523

GO:1903753

GO:2000566

Hs.5103.0.A1_3p_at

ILMN_1695640

ILMN_2246328

PH_hs_0035496

g7706279_3p_a_at

Participates

as an output of

PTPN22 dissociates from CSK (Homo sapiens)

as a component of

PTPN22:CSK [cytosol] (Homo sapiens)

Inferred To

ptpn22 [cytosol] (Danio rerio)

PTPN22 [cytosol] (Bos taurus)

PTPN22 [cytosol] (Canis familiaris)

PTPN22 [cytosol] (Gallus gallus)

PTPN22 [cytosol] (Mus musculus)

PTPN22 [cytosol] (Sus scrofa)

Ptpn22 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001180360.1, NP_057051.3, NP_036543.4, NP_001295226.1

Guide to Pharmacology - Targets

3084

OpenTargets

ENSG00000134242

ZINC - Substances

PTN22_HUMAN

ZINC target

Q9Y2R2

ZINC - Biogenic

PTN22_HUMAN

PRO

Q9Y2R2

PDB

3BRH, 2QCJ, 2QCT, 3OMH, 7AAM, 3H2X, 2P6X, 4J51, 3OLR

GeneCards

Q9Y2R2

HPA

ENSG00000134242-PTPN22

Ensembl

ENSP00000433141, ENSG00000134242, ENST00000460620

Pharos - Targets

Q9Y2R2

ZINC - Predictions - Purchasable

PTN22_HUMAN

Orphanet

21583

HMDB Protein

HMDBP08933

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.783	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P20963 CD247			0.632	4
UniProt:O75563 SKAP2	1	SKAP2 [cytosol] (R-HSA-390927)	0.611	3
UniProt:P43403 ZAP70	3	ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.602	4
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.591	6
UniProt:Q60803	3	Traf3 [cytosol] (R-MMU-936556) Traf3 [cytosol] (R-MMU-914241) Traf3 [cytosol] (R-MMU-936402)	0.544	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.544	2

Cite Us!