Reactome | GTSE1 binds MAPRE1 (EB1) at microtubule plus ends

GTSE1 binds MAPRE1 (EB1) at microtubule plus ends

Stable Identifier

R-HSA-8852298

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GTSE1 binds MAPRE1 (EB1) at microtubule plus ends

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During interphase, GTSE1 localizes to the growing plus-end tip of microtubules by binding to the microtubule plus end protein MAPRE1 (EB1). This interaction involves two SKIP-like EB1-interaction motifs of GTSE1 and the C-terminal EB-homology (EBH) domain of MAPRE1. The interaction between GTSE1 and MAPRE1 is evolutionarily conserved. The interaction between GTSE1 and MAPRE1 at growing microtubule plus ends promotes cell migration, likely through microtubule-induced disassembly of focal adhesions. GTSE1 expression levels in G1 phase correlate with invasiveness of breast cancer cell lines (Scolz et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23236459	GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration Scolz, M, Widlund, PO, Piazza, S, Bublik, DR, Reber, S, Peche, LY, Ciani, Y, Hubner, N, Isokane, M, Monte, M, Ellenberg, J, Hyman, AA, Schneider, C, Bird, AW	PLoS ONE	2012