Starting in mitotic prometaphase, GTSE1 becomes phosphorylated at threonine residues T513 and T526 (and possibly other sites), located adjacent to the two SKIP-like motifs involved in binding to MAPRE1 (EB1). Mitotic phosphorylation of GTSE1 inhibits its association with microtubule plus ends. CDK1 activity inhibits the association of recombinant human GTSE1 with microtubule plus ends in Xenopus extracts, but it is not certain whether CDK1 or another mitotic kinase phosphorylates GTSE1 (Scolz et al. 2012).
Piazza, S, Hyman, AA, Scolz, M, Schneider, C, Bublik, DR, Peche, LY, Ellenberg, J, Widlund, PO, Hubner, N, Reber, S, Monte, M, Bird, AW, Ciani, Y, Isokane, M
protein serine/threonine kinase activity of Mitotic kinase [cytosol]
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