GTSE1 translocates to the nucleus

Stable Identifier
R-HSA-8852331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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GTSE1 translocates to the nucleus
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PLK1-mediated phosphorylation of GTSE1 is needed for nuclear accumulation of GTSE1, probably because it exposes the nuclear localization signal (NLS) of GTSE1 to the nuclear import machinery. Nuclear localization of GTSE1 is not needed for normal G2 phase progression, but is needed for the G2 checkpoint recovery (cell cycle re-entry after G2 checkpoint arrest) (Liu et al. 2010).
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Orthologous Events
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Authored
Orlic-Milacic, M  (2016-01-15)
Reviewed
Bird, AW  (2016-01-22)
Created
Orlic-Milacic, M  (2016-01-15)
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