Reactome | COLEC10 [extracellular region]

COLEC10 [extracellular region]

Stable Identifier

R-HSA-8852492

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Collectin-10, COL10_HUMAN, CL-L1

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC10 [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC10 [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        CL-LK binds carbohydrates on target cell surface (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC10 [extracellular region] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        CL-LK:MASP1 dimer:MASP2 dimer [extracellular region] (Homo sapiens)
        
        CL-LK [extracellular region] (Homo sapiens)
        
        COLEC10 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6Z7 COLEC10

Gene Names

COLEC10, CLL1, UNQ366/PRO702

Chain

signal peptide:1-27, chain:28-277

Reference Genes

BioGPS Gene:10584 COLEC10

COSMIC (genes):COLEC10 COLEC10

CTD Gene:10584 COLEC10

dbSNP Gene:10584 COLEC10

ENSEMBL:ENSG00000184374 COLEC10

HGNC:2220 COLEC10

KEGG:hsa:10584 COLEC10

Monarch:10584 COLEC10

NCBI Gene:10584 COLEC10

OMIM:607620 COLEC10

UCSC:Q9Y6Z7 COLEC10

Reference Transcript

Other Identifiers

10584

11736982_at

17072110

207420_PM_at

207420_at

3113132

3113134

3113136

3113138

3113139

3113140

3113144

3113145

3113147

3113148

3113149

3113150

3113151

3113152

3113153

32292_at

8148029

A_14_P106637

A_14_P202251

A_32_P212958

GE81637

GO:0001867

GO:0002376

GO:0002752

GO:0005515

GO:0005537

GO:0005576

GO:0005581

GO:0005615

GO:0005737

GO:0005768

GO:0005771

GO:0005794

GO:0006508

GO:0009897

GO:0031410

GO:0042056

GO:0043226

GO:0045087

GO:0048018

GO:0048856

GO:0050918

GO:0098542

GO:0098772

GO:1903028

GO:1904888

GO:1905370

HMNXSV003012134

ILMN_1662962

TC08000694.hg

g5453618_3p_at

Participates

as a component of

CL-LK [extracellular region] (Homo sapiens)

Inferred To

Colec10 [extracellular region] (Mus musculus)

Colec10 [extracellular region] (Rattus norvegicus)

COLEC10 [extracellular region] (Bos taurus)

COLEC10 [extracellular region] (Canis familiaris)

COLEC10 [extracellular region] (Gallus gallus)

COLEC10 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_006429.2, NP_001311024.1

ENSEMBL

ENSG00000184374, ENSP00000332723, ENST00000332843

OpenTargets

ENSG00000184374

GeneCards

COLEC10

HPA

ENSG00000184374-COLEC10

PRO

Q9Y6Z7

Pharos - Targets

Q9Y6Z7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBS3 DNAJB9	1	DNAJB9 [endoplasmic reticulum membrane] (R-HSA-381010)	0.527	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [specific granule membrane] (R-HSA-6799552) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [azurophil granule membrane] (R-HSA-6799559) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.527	2