EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane]

Stable Identifier
R-HSA-8853148
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
ERLIN2(1-186)-FGFR1(c.-88-p.822) fusion
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Kalyana-Sundaram, S, Chinnaiyan, AM, Wang, R, Tomlins, SA, Ateeq, B, Cao, X, Cheng, AJ, Rhodes, DR, Hussain, MH, Kunju, LP, Lonigro, RJ, Robinson, DR, Sadis, S, Talpaz, M, Lin, SF, Pienta, KJ, Feng, FY, Roychowdhury, S, Vats, P, Wu, YM, Wyngaard, P, Su, F, Khazanov, N, Siddiqui, J, Zalupski, MM

Cancer Discov 2013
External Reference Information
External Reference
Gene Names
ERLIN2, C8orf2, SPFH2, UNQ2441/PRO5003/PRO9924
Chain
chain:1-339
Other Identifiers
11160
11731043_s_at
11731044_at
11731045_s_at
11735259_a_at
11735260_s_at
11741586_a_at
11741587_x_at
11745025_a_at
11745026_a_at
11759837_at
17067902
221542_PM_s_at
221542_s_at
221543_PM_s_at
221543_s_at
238615_PM_at
238615_at
3094237
3094244
3094246
3094247
3094248
3094249
3094250
3094251
3094252
3094253
3094254
3094255
3094256
3094257
3094258
3094259
3094260
3094261
3094262
3094263
3094264
3094265
3094266
3094267
3094269
3094273
3094281
3094283
3094285
3094287
3094288
3094289
37798_at
49388_at
79608_at
8145835
83018_at
A_23_P123440
A_24_P21266
A_24_P372217
A_24_P765540
A_33_P3363061
GE81734
GO:0005515
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006629
GO:0008202
GO:0008203
GO:0008289
GO:0015485
GO:0016020
GO:0023052
GO:0030163
GO:0030433
GO:0031625
GO:0032933
GO:0032991
GO:0043226
GO:0045121
GO:0045540
GO:0045541
GO:0045717
HMNXSV003019948
HMNXSV003021170
HMNXSV003048012
Hs.125849.0.S2_3p_a_at
Hs.143848.0.A1_3p_at
ILMN_1700549
PH_hs_0031629
TC08000277.hg
g10241715_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
Replacement of residues 186 to 186 by MVSLKRRIELTVEYPWRCGALSPTSNCRTG
Name
Insertion of residues 1 to 822 at 187 from UniProt:P11362 FGFR1
Coordinate
187
Disease
Name Identifier Synonyms
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P11021 HSPA5  6 0.643 3
 UniProt:P27824 CANX  2 0.643 3
 UniProt:P13569 CFTR  17 0.615 10
 UniProt:Q86TM6 SYVN1  1 0.564 2
 UniProt:Q9NWM8 FKBP14 gene  1 0.527 2
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