FGFR2 fusions autophosphorylate

Stable Identifier
R-HSA-8853313
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FGFR2 fusions autophosphorylate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FGFR2 fusions in cholangiocarcinoma and cancers of the breast, lung and thyroid have been shown to promote anchorage independent growth, cellular proliferation and tumorigenesis. In some cases, such as for FGFR2-AHCYL1 and FGFR2-BICC1 fusions in cholangiocarcinoma, these activities have been shown to depend on the FGFR2 kinase domain, suggesting that the fusions undergo autophosphorylation after oligomerization, as is the case for WT FGFR2. FGFR2 fusions, where tested, also show sensitivity to kinase inhibitors such as PD173074 and pazopanib (Arai et al, 2013; Wu et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).
Literature References
PubMed ID Title Journal Year
22975805 The transcriptional landscape and mutational profile of lung adenocarcinoma

Kang, JH, Seo, JS, Park, IK, Rhee, H, Kim, JI, Kim, JO, Lee, SH, Lee, WC, Jung, YJ, Bleazard, T, Lee, ER, Kim, J, Yu, SB, Shin, JY, Kim, YT, Lee, J, Ju, YS, Shin, JY, Kang, CH, Lee, JK

Genome Res. 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Kalyana-Sundaram, S, Chinnaiyan, AM, Wang, R, Tomlins, SA, Ateeq, B, Cao, X, Cheng, AJ, Rhodes, DR, Hussain, MH, Kunju, LP, Lonigro, RJ, Robinson, DR, Sadis, S, Talpaz, M, Lin, SF, Pienta, KJ, Feng, FY, Roychowdhury, S, Vats, P, Wu, YM, Wyngaard, P, Su, F, Khazanov, N, Siddiqui, J, Zalupski, MM

Cancer Discov 2013
24122810 Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Hosoda, F, Totoki, Y, Furuta, K, Kosuge, T, Okusaka, T, Shibata, T, Arai, Y, Ojima, H, Shimada, K, Shirota, T, Nakamura, H, Hama, N

Hepatology 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Zhang, W, Annala, M, Engels, M

J. Pathol. 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of FGFR2 fusion dimers [plasma membrane]

Physical Entity
FGFR2 fusion dimers [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Functional status

Gain of function of FGFR2 fusion dimers [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2016-01-09)
Reviewed
Grose, RP  (2016-01-25)
Created
Rothfels, K  (2016-01-22)
Cite Us!