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PHLDA1 binds AURKA
Stable Identifier
R-HSA-8853429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Interaction between PHLDA1 and AURKA (Homo sapiens)
PHLDA1 binds AURKA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Aurora kinase A binds PHLDA1 (TDAG51) and the two proteins co-localize in the cytosol (Johnson et al. 2011). Although phosphorylation of AURKA at threonine residue T288 within the catalytic loop of AURKA is needed for AURKA kinase activity (Walter et al. 2000), AURKA phosphorylation has not been specifically examined in the context of AURKA interaction with PHLDA1 and AURKA is therefore shown as unphosphorylated.
Literature References
PubMed ID
Title
Journal
Year
21807936
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer
Badve, S
,
Ghosh, S
,
Chang, KH
,
Johnson, EO
,
Mehta, R
,
Shah, K
,
de Pablo, Y
J. Cell. Sci.
2011
Participants
Input
AURKA [cytosol]
(Homo sapiens)
PHLDA1 [cytosol]
(Homo sapiens)
Output
AURKA:PHLDA1 [cytosol]
(Homo sapiens)
Participates
as an event of
Interaction between PHLDA1 and AURKA (Homo sapiens)
Orthologous Events
PHLDA1 binds AURKA (Bos taurus)
PHLDA1 binds AURKA (Canis familiaris)
PHLDA1 binds AURKA (Danio rerio)
PHLDA1 binds AURKA (Gallus gallus)
PHLDA1 binds AURKA (Mus musculus)
PHLDA1 binds AURKA (Rattus norvegicus)
PHLDA1 binds AURKA (Sus scrofa)
PHLDA1 binds AURKA (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2016-01-29)
Reviewed
Shah, K (2016-02-04)
Created
Orlic-Milacic, M (2016-01-23)
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