2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10

Stable Identifier
R-HSA-8853753
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
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Tyrosine-phosphorylated RET can bind GRB7 or GRB10 via tyrosine-905 (Pandey et al. 1995, 1996).

Literature References
PubMed ID Title Journal Year
7665556 The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10

Pandey, A, Dixit, VM, Duan, H, Di Fiore, PP

J. Biol. Chem. 1995
8631863 Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7

Dixon, JE, Pandey, A, Liu, X, Dixit, VM, Di Fiore, PP

J. Biol. Chem. 1996
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Orthologous Events
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Sus scrofa)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Xenopus tropicalis)
Authored
Jupe, S  (2016-01-25)
Reviewed
Luo, W  (2016-05-17)
Morales, D  (2016-05-06)
Created
Jupe, S  (2016-01-25)
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