ARTN binds RET:GFRA1,GFRA3

Stable Identifier
R-HSA-8853800
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ARTN binds RET:GFRA1,GFRA3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Artemin (ARTN) is a ligand for GDNF family receptor-alpha (GFRA) 1 and 3, preferentially binding GFRA3 (Baloh et al. 1998).

Literature References
PubMed ID Title Journal Year
9883723 Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

Enomoto, H, Lampe, PA, Simburger, KS, Johnson, EM, Milbrandt, J, Fahrner, TJ, Tansey, MG, Baloh, RH, Araki, T, Leitner, ML

Neuron 1998
Participants
Input
Output
Participates
as an event of
Orthologous Events
ARTN binds RET:GFRA1,GFRA3 (Bos taurus)
ARTN binds RET:GFRA1,GFRA3 (Danio rerio)
ARTN binds RET:GFRA1,GFRA3 (Mus musculus)
ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)
ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)
ARTN binds RET:GFRA1,GFRA3 (Xenopus tropicalis)
Authored
Jupe, S  (2016-01-25)
Reviewed
Luo, W  (2016-05-17)
Morales, D  (2016-05-06)
Created
Jupe, S  (2016-01-25)
Cite Us!