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VENTX binds the CDKN2A gene
Stable Identifier
R-HSA-8853920
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
VENTX binds the CDKN2A gene (Homo sapiens)
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VENTX binds to the CDKN2A promoter that regulates the expression of the p16-INK4A cyclin-dependent kinase inhibitor. Binding of VENTX to an alternative CDKN2A promoter, which regulates the expression of p14-ARF, has not been examined (Wu et al. 2011). CDKN2A locus encodes tumor suppressor genes p16INK4A and p14ARF (p19ARF in mouse). p16INK4A and p14ARF are expressed from different promoters and translated in different reading frames. They use different exon 1 (exon 1-alpha in p16INK4A and exon 1-beta in p14ARF) but share exons 2 and 3. Therefore, while their mRNAs are homologous, they share no similarity at the amino acid sequence level and perform distinct functions in the cell (Quelle et al. 1995).
Literature References
PubMed ID
Title
Journal
Year
21325273
VentX trans-activates p53 and p16ink4a to regulate cellular senescence
Hager, M
,
Freeman, MR
,
Xiao, S
,
Ke, W
,
Gao, H
,
Wu, X
,
Zhu, Z
J. Biol. Chem.
2011
Participants
Input
CDKN2A gene [nucleoplasm]
(Homo sapiens)
VENTX [nucleoplasm]
(Homo sapiens)
Output
VENTX:CDKN2A Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transcriptional Regulation by VENTX (Homo sapiens)
Authored
Orlic-Milacic, M (2019-06-28)
Reviewed
Vegi, NM (2019-10-18)
Created
Orlic-Milacic, M (2016-01-26)
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