Reactome | TBC1D7 [cytosol]

TBC1D7 [cytosol]

Stable Identifier

R-HSA-8854154

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TBC1 domain family member 7, TBCD7_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P49815 TSC2

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External Reference Information

External Reference

UniProt:Q9P0N9 TBC1D7

Gene Names

TBC1D7, TBC7, HSPC239

Chain

chain:1-293

Reference Genes

BioGPS Gene:107080638 TBC1D7

BioGPS Gene:51256 TBC1D7

COSMIC (genes):TBC1D7 TBC1D7

CTD Gene:51256 TBC1D7

dbSNP Gene:107080638 TBC1D7

dbSNP Gene:51256 TBC1D7

ENSEMBL:ENSG00000145979 TBC1D7

HGNC:21066 TBC1D7

Monarch:107080638 TBC1D7

Monarch:51256 TBC1D7

NCBI Gene:107080638 TBC1D7

NCBI Gene:51256 TBC1D7

OMIM:612655 TBC1D7

UCSC:Q9P0N9 TBC1D7

Reference Transcript

Other Identifiers

107080638

11728034_a_at

1563839_PM_at

1563839_at

17015715

17015739

223461_PM_at

223461_at

2942307

2942313

2942329

2942336

2942337

2942338

2942339

2942340

2942341

2942342

2942343

2942344

2942346

2942347

2942348

2942349

2942351

2942352

2942353

2942354

2942355

2942356

2942357

2942358

51256

55095_at

8123961

A_23_P111273

A_33_P3311907

GE487618

GE54925

GE577636

GE87007

GO:0005096

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005815

GO:0005829

GO:0009267

GO:0016020

GO:0031267

GO:0031398

GO:0031410

GO:0031982

GO:0032007

GO:0033596

GO:0036064

GO:0043226

GO:0043547

GO:0070848

GO:0090630

GO:0098772

GO:1902018

GO:1904262

HMNXSV003009320

Hs2.434224.1.S1_3p_at

ILMN_1661622

PH_hs_0000913

PH_hs_0035340

g7106867_3p_at

Participates

as a component of

TBC1D7:TSC1:TSC2 [cytosol] (Homo sapiens)

as an input of

TBC1D7 binds the TSC1-TSC2 complex (Homo sapiens)

Inferred To

TBC1D7 [cytosol] (Bos taurus)

TBC1D7 [cytosol] (Canis familiaris)

TBC1D7 [cytosol] (Dictyostelium discoideum)

TBC1D7 [cytosol] (Gallus gallus)

TBC1D7 [cytosol] (Sus scrofa)

TBC1d7 [cytosol] (Drosophila melanogaster)

tbc1d7 [cytosol] (Danio rerio)

tbc1d7 [cytosol] (Xenopus tropicalis)

Tbc1d7 [cytosol] (Mus musculus)

Tbc1d7 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000145979

ENSEMBL

ENST00000379307, ENSP00000348813, ENSP00000368602, ENST00000379300, ENST00000343141, ENSP00000368609, ENST00000606214, ENSP00000475727, ENSP00000343100, ENST00000356436

HPA

ENSG00000145979-TBC1D7

PRO

Q9P0N9

Pharos - Targets

Q9P0N9

Orphanet

TBC1D7

PDB

3QWL, 5EJC, 4Z6Y, 7DL2, 5ULO

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BUZ4 TRAF4			0.841	9
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.781	7
UniProt:Q9UJC3 HOOK1			0.781	7
UniProt:O43805 SSNA1	1	SSNA1 [cytosol] (R-HSA-380255)	0.781	7
UniProt:O95751 LDOC1			0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	8
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.71	5
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.696	5
UniProt:Q9H3L0 MMADHC	8	MMADHC [cytosol] (R-HSA-3149529) MMADHC R250* [cytosol] (R-HSA-3318608) MMADHC T182N [cytosol] (R-HSA-3318599) MMADHC L259P [cytosol] (R-HSA-3318587) MMADHC Y249C [cytosol] (R-HSA-3318584) MMADHC Y140* [cytosol] (R-HSA-3318633) MMADHC R54* [cytosol] (R-HSA-3318620) MMADHC S20* [cytosol] (R-HSA-3318573)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:Q96KN7 RPGR1			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.528	3
UniProt:Q86VH2 KIF27	1	KIF27 [cytosol] (R-HSA-8849363)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q8N448 LNX2			0.488	2

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