TBC1D25 (OATL1) binds ATG8 homologues

Stable Identifier
R-HSA-8854588
Type
Reaction [binding]
Species
Homo sapiens
Compartment
autophagosome membrane, autophagosome
ReviewStatus
5/5
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TBC1D25 (OATL1) binds ATG8 homologues
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TBC (Tre2/Bub2/Cdc16) domain family member 25 (TBC1D25 also referred as OATL1), a putative GTPase activating protein (GAP), is recruited to autophagosomes through an interaction with ATG8 homologues (LC3, GABARAP and GATE-16), and is involved in the fusion between autophagosomes and lysosomes through its GAP activity. OATL1 delays autophagosomal maturation by inhibiting the encounter between autophagosomes and lysosomes (Itoh et al. 2011).
Literature References
PubMed ID Title Journal Year
21383079 OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

Fukuda, M, Itoh, T, Uemura, T, Waguri, S, Kanno, E

J. Cell Biol. 2011
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Orthologous Events
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TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)
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TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)
TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)
TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)
TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)
TBC1D25 (OATL1) binds ATG8 homologues (Saccharomyces cerevisiae)
TBC1D25 (OATL1) binds ATG8 homologues (Schizosaccharomyces pombe)
TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)
Authored
Garapati, P V  (2016-01-27)
Created
Garapati, P V  (2016-01-28)
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