Reactome | TBC1D25 [autophagosome]

TBC1D25 [autophagosome]

Stable Identifier

R-HSA-8854607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome

Synonyms

TBC1 domain family member 25, TBC25_HUMAN, OATL1

Locations in the PathwayBrowser for interactor UniProt:Q8TCE9 PPL13

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External Reference Information

External Reference

UniProt:Q3MII6 TBC1D25

Gene Names

TBC1D25, OATL1

Chain

chain:1-688

Reference Genes

BioGPS Gene:4943 TBC1D25

COSMIC (genes):TBC1D25 TBC1D25

CTD Gene:4943 TBC1D25

dbSNP Gene:4943 TBC1D25

ENSEMBL:ENSG00000068354 TBC1D25

ENSEMBL_homo_sapiens_GENE:ENSG00000068354.16 TBC1D25

HGNC:8092 TBC1D25

KEGG Gene (Homo sapiens):4943 TBC1D25

Monarch:4943 TBC1D25

NCBI Gene:4943 TBC1D25

OMIM:311240 TBC1D25

UCSC:Q3MII6 TBC1D25

Reference Transcript

Other Identifiers

11722611_at

11748734_s_at

11748753_a_at

17103340

226173_PM_at

226173_at

227820_PM_at

227820_at

3976691

3976693

3976694

3976696

3976698

3976699

3976700

3976701

3976702

4943

54513_at

64213_at

8167314

A_23_P159693

GE88075

GO:0005096

GO:0005515

GO:0005737

GO:0005773

GO:0005776

GO:0006914

GO:0031410

GO:0043226

GO:0098772

GO:1901096

HMNXSV003034224

Hs.30619.0.S1_3p_at

Hs.6570.0.A1_3p_at

ILMN_1681855

ILMN_1768491

PH_hs_0031128

TC0X000254.hg

TC0X001697.hg

Participates

as a component of

TBC1D25:ATG8 homoogues [autophagosome membrane] (Homo sapiens)

as an input of

TBC1D25 (OATL1) binds ATG8 homologues (Homo sapiens)

This entity regulates

Positively

TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)

Inferred To

gyp7 [autophagosome] (Schizosaccharomyces pombe)

Dmel\CG8155 [autophagosome] (Drosophila melanogaster)

GYP7 [autophagosome] (Saccharomyces cerevisiae)

TBC1D25 [autophagosome] (Bos taurus)

TBC1D25 [autophagosome] (Canis familiaris)

TBC1D25 [autophagosome] (Dictyostelium discoideum)

TBC1D25 [autophagosome] (Gallus gallus)

TBC1D25 [autophagosome] (Sus scrofa)

Tbc1d25 [autophagosome] (Mus musculus)

Tbc1d25 [autophagosome] (Rattus norvegicus)

Cross References

RefSeq

NP_002527.1, NP_001335191.1

OpenTargets

ENSG00000068354

GeneCards

Q3MII6

HPA

ENSG00000068354-TBC1D25

Ensembl

ENSG00000068354, ENSP00000476787, ENST00000481090, ENSP00000365962, ENST00000376771

PRO

Q3MII6

Pharos - Targets

Q3MII6

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.742	5
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.742	5
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.589	2
UniProt:Q8TCE9 PPL13			0.556	3
UniProt:Q9NZI2-2 Q9NZI22-1			0.556	3
UniProt:Q8N7C3 TRIMM			0.556	3
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [autophagosome membrane] (R-HSA-5683638) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [cytosol] (R-HSA-5679223)	0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q8IXW0 LMTD2			0.556	3
UniProt:Q659C4-6 LARP1B			0.556	3
UniProt:P61019 RAB2A	3	GGC-RAB2A [cytosol] (R-HSA-8873963) RAB2A [cytosol] (R-HSA-8873716) RAB2A [Golgi membrane] (R-HSA-2422386)	0.556	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.527	2

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