TBC1D14 binds RAB11 and ULK1

Stable Identifier
R-HSA-8854759
Type
Reaction [binding]
Species
Homo sapiens
Compartment
recycling endosome membrane
ReviewStatus
5/5
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TBC1D14 binds RAB11 and ULK1
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TBC (Tre2/Bub2/Cdc16) domain family, member 14 (TBC1D14) is a putative Rab GTPase activating protein (GAP) member that binds to activated Rab11 and regulates starvation-induced autophagy. TBC1D14 does not have the GAP activity and may function as Rab11 effector. TBC1D14 also colocalizes and interacts with the autophagy kinase ULK1. Overexpression of TBC1D14 causes tubulation of recycling endosomes (REs), accumulation of the ULK1 complex and Rab11 on REs, and inhibition of vesicular transport from the RE (Longatti et al. 2012).
Literature References
PubMed ID Title Journal Year
22613832 TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

Tooze, SA, Barr, FA, Longatti, A, Razi, M, Yoshimura, S, Lamb, CA

J. Cell Biol. 2012
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Orthologous Events
TBC1D14 binds RAB11 and ULK1 (Bos taurus)
TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)
TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)
TBC1D14 binds RAB11 and ULK1 (Gallus gallus)
TBC1D14 binds RAB11 and ULK1 (Mus musculus)
TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)
TBC1D14 binds RAB11 and ULK1 (Sus scrofa)
Authored
Garapati, P V  (2016-01-27)
Created
Garapati, P V  (2016-01-28)
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