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NR1H3 [nucleoplasm]
Stable Identifier
R-HSA-8854957
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Oxysterols receptor LXR-alpha, NR1H3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O60341%20KDM1A
Expand all
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
NR1H3 mRNA is translated (Homo sapiens)
NR1H3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13133 NR1H3
Gene Names
NR1H3, LXRA
Chain
chain:1-447
Reference Genes
BioGPS Gene:10062 NR1H3
COSMIC (genes):NR1H3 NR1H3
CTD Gene:10062 NR1H3
dbSNP Gene:10062 NR1H3
ENSEMBL:ENSG00000025434 NR1H3
ENSEMBL_homo_sapiens_GENE:ENSG00000025434.19 NR1H3
HGNC:7966 NR1H3
KEGG Gene (Homo sapiens):10062 NR1H3
Monarch:10062 NR1H3
NCBI Gene:10062 NR1H3
OMIM:602423 NR1H3
UCSC:Q13133 NR1H3
Reference Transcript
RefSeq:XM_005252706.1 NR1H3
RefSeq:XM_005252709.1 NR1H3
RefSeq:NM_005693.3 NR1H3
RefSeq:XM_006718113.1 NR1H3
RefSeq:XM_011519805.2 NR1H3
RefSeq:NM_001130102.2 NR1H3
RefSeq:XM_005252713.3 NR1H3
RefSeq:XM_017017058.1 NR1H3
RefSeq:XM_005252705.1 NR1H3
RefSeq:XM_006718116.1 NR1H3
RefSeq:XM_005252707.4 NR1H3
RefSeq:XM_005252710.1 NR1H3
RefSeq:XM_006718115.1 NR1H3
RefSeq:NM_001130101.2 NR1H3
RefSeq:XM_006718112.1 NR1H3
Other Identifiers
10062
11719393_a_at
16724485
203920_PM_at
203920_at
33106_at
3329686
3329689
3329690
3329691
3329692
3329693
3329694
3329695
3329696
3329697
3329699
3329700
3329701
3329702
3329703
3329705
3329707
3329708
3329711
3329713
3329714
3329715
3329716
3329717
3329718
3329725
512_at
7939751
A_14_P122332
A_23_P47135
A_33_P3237775
GE81543
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006954
GO:0008270
GO:0008289
GO:0009755
GO:0010745
GO:0010867
GO:0010875
GO:0010887
GO:0015485
GO:0016071
GO:0016192
GO:0022600
GO:0023052
GO:0030154
GO:0030522
GO:0031490
GO:0032369
GO:0032376
GO:0032411
GO:0032570
GO:0032810
GO:0034145
GO:0036151
GO:0042632
GO:0042752
GO:0042789
GO:0043031
GO:0043226
GO:0043235
GO:0043277
GO:0043565
GO:0044255
GO:0045723
GO:0045861
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0046889
GO:0048550
GO:0050728
GO:0051006
GO:0051247
GO:0055088
GO:0055092
GO:0060089
GO:0060336
GO:0070328
GO:0071222
GO:0090188
GO:0090341
GO:0090575
GO:0098542
GO:0120163
GO:0140110
GO:1903573
HMNXSV003022469
ILMN_1814022
PH_hs_0033433
TC11000405.hg
U22662_at
g5031892_3p_at
Participates
as an output of
NR1H3 mRNA is translated (Homo sapiens)
as a component of
NR1H3:RXRB [nucleoplasm] (Homo sapiens)
NR1H3:RXRA [nucleoplasm] (Homo sapiens)
as a member of
NR1H2,NR1H3 [nucleoplasm] (Homo sapiens)
Inferred To
NR1H3 [nucleoplasm]
(Bos taurus)
NR1H3 [nucleoplasm]
(Canis familiaris)
NR1H3 [nucleoplasm]
(Gallus gallus)
NR1H3 [nucleoplasm]
(Sus scrofa)
EcR [nucleoplasm]
(Drosophila melanogaster)
Nr1h3 [nucleoplasm]
(Mus musculus)
Nr1h3 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_005252770.1
,
XP_005252764.1
,
NP_001123573.1
,
XP_005252762.1
,
XP_006718178.1
,
NP_005684.2
,
XP_006718175.1
,
XP_016872547.1
,
XP_006718176.1
,
XP_005252767.1
,
XP_005252763.1
,
XP_006718179.1
,
XP_011518107.1
,
NP_001123574.1
,
XP_005252766.1
Guide to Pharmacology - Targets
602
OpenTargets
ENSG00000025434
ZINC - Substances
NR1H3_HUMAN
ZINC target
Q13133
ZINC - Biogenic
NR1H3_HUMAN
PRO
Q13133
PDB
5HJS
,
3IPU
,
3IPQ
,
5AVL
,
1UHL
,
5AVI
,
3IPS
ZINC - Metabolites
NR1H3_HUMAN
HPA
ENSG00000025434-NR1H3
GeneCards
Q13133
Ensembl
ENSP00000387946
,
ENSP00000384745
,
ENSP00000385801
,
ENST00000441012
,
ENST00000467728
,
ENSG00000025434
,
ENST00000405853
,
ENSP00000378793
,
ENST00000395397
,
ENSP00000420656
,
ENST00000407404
Pharos - Targets
Q13133
ZINC - Predictions - Purchasable
NR1H3_HUMAN
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48443 RXRG
1
RXRG [nucleoplasm]
(R-HSA-446170)
0.742
7
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.691
15
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.611
5
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.609
8
UniProt:O60869 EDF1
0.581
4
UniProt:P28702 RXRB
1
RXRB [nucleoplasm]
(R-HSA-446163)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.525
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
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