Reactome | ANGPTL8 binds ANGPTL3

ANGPTL8 binds ANGPTL3

Stable Identifier

R-HSA-8856525

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Angiopoietin-like protein 8 (ANGPTL8, aka betatrophin, lipasin) can regulate ANGPTL3 by binding to and promoting cleavage of it, thereby further activating ANGPTL3 (a protein that plays a critical role in the regulation of triglyceride and cholesterol plasma levels, via reversible inhibition of lipoprotein lipase activity) (Ren et al. 2012, Quagliarini et al. 2012, Li & Teng 2014). The exact mechanism of action of ANGPTL8 on ANGPTL3 is poorly understood.

Literature References

PubMed ID	Title	Journal	Year
22569073	Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism Ren, G, Smas, CM, Kim, JY	Am. J. Physiol. Endocrinol. Metab.	2012
24960069	Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome Li, Y, Teng, C	J Drug Target	2014
23150577	Atypical angiopoietin-like protein that regulates ANGPTL3 Valenzuela, DM, Hobbs, HH, Kozlitina, J, Hyde, R, Cohen, JC, Murphy, AJ, Grishin, NV, Quagliarini, F, Boerwinkle, E, Wang, Y	Proc. Natl. Acad. Sci. U.S.A.	2012