EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene

Stable Identifier
R-HSA-8856930
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EPAS1 (HIF2A) and dexamethasone-activated glucocorticoid receptor NR3C1 (GCR or GR), in the presence of the NR3C1 co-factor PELP1, cooperatively bind to adjacent hypoxia response and glucocorticoid response elements in the PTK6 gene promoter. The cooperative binding of EPAS1 and NR3C1 to the PTK6 gene promoter may be facilitated by p38 MAPK-mediated phosphorylation of NR3C1 on serine residue S134. EPAS1 expression can also be stimulated by the activated NR3C1. EPAS1 and NR3C1-mediated activation of PTK6 expression may play an important role in the progression of the triple negative breast cancer (Regan Anderson et al. 2016).
Literature References
PubMed ID Title Journal Year
26825173 Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer

Regan Anderson, TM, Lange, CA, Seagroves, TN, Ma, SH, Helle, TM, Krutilina, R, Knutson, TP, Cidlowski, JA, Raj, GV

Cancer Res. 2016
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2016-02-11)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2016-02-12)
Cite Us!