LINC01139 facilitates PTK6 autophosphorylation

Stable Identifier
R-HSA-8857577
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The long non-coding RNA LINC01139 (LINK-A) induces conformational change of PTK6 (BRK), which facilitates PTK6 autophosphorylation on tyrosine residue Y351 and possibly other sites (Lin et al. 2016).

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Lin, A, Li, C, Xing, Z, Hu, Q, Liang, K, Han, L, Wang, C, Hawke, DH, Wang, S, Zhang, Y, Wei, Y, Ma, G, Park, PK, Zhou, J, Zhou, Y, Hu, Z, Zhou, Y, Marks, JR, Liang, H, Hung, MC, Lin, C, Yang, L

Nat. Cell Biol. 2016
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane]

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